A charged-particle microbeam .2. A single-particle micro-collimation and detection system.

M. Folkard, B. Vojnovic, K.J. Hollis, A.G. Bowey, S.J. Watts, Giuseppe Schettino, Kevin Prise, B.D. Michael

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

The use of a charged-particle microbeam provides a unique opportunity to control precisely, the number of particles traversing individual cells and the localization of dose within the cell. The accuracy of 'aiming' and of delivering a precise number of particles crucially depends on the design and implementation of the collimation and detection system. This report describes the methods available for collimating and detecting energetic particles in the context of a radiobiological microbeam. The arrangement developed at the Gray Laboratory uses either a 'V'-groove or a thick-walled glass capillary to achieve 2-5 mu m spatial resolution. The particle detection system uses an 18 mu m thick transmission scintillator and photomultiplier tube to detect particles with >99% efficiency.
Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalInternational journal of radiation biology
Volume72
Publication statusPublished - 1997

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