Abstract
D-Stereoselective peptidases that degrade non-ribosomal peptides (NRPs) were recently discovered and could have serious implications for the future of NRPs as antibiotics. Herein, we report chemical modifications that can be used to impart re-sistance to the D-peptidases BogQ and TriF. New tridecaptin A analogues were synthesized that retain strong antimicrobial activity and have significantly enhanced D-peptidase stability. In vitro assays confirmed that synthetic analogues retain the ability to bind to their cellular receptor, peptidoglycan intermediate lipid II.
Original language | English |
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Pages (from-to) | 10466-10472 |
Journal | Journal of Medicinal Chemistry |
Volume | 62 |
Issue number | 22 |
DOIs | |
Publication status | Published - 27 Nov 2019 |
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Dive into the research topics of 'A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases'. Together they form a unique fingerprint.Student Theses
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
Author: Ballantine, R., Jul 2021Supervisor: Cochrane, S. (Supervisor) & Stevenson, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy