A cleavable network based on crosslinked star polymers containing acid-labile diacetal crosslinks: Synthesis, characterization and hydrolysis

Efrosyni Themistou, Costas S. Patrickios

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A hydrolyzable model network comprising interconnected star polymers was prepared by the sequential group transfer polymerization of methyl methacrylate and the acid-labile diacetal-based dimethacrylate crosslinker bis[(2-methacryloyloxy)ethoxymethyl] ether. in contrast to other polymer networks previously synthesized by our group, all the branching points of this polymer network were found to hydrolyze under mildly acidic conditions, giving a linear copolymer with the theoretically expected molecular weight and composition. The ease of hydrolysis of this polymer network renders it a good candidate for use in the biomedical field. The characterization of the synthesized network, its linear and star polymer precursors and the hydrolysis products of the network and its precursors, by a variety of techniques, established the successful synthesis and hydrolysis of this well-defined polymer nanostructure.
Original languageEnglish
Pages (from-to)1021-1028
JournalMacromolecular Chemistry and Physics
Volume209
Issue number10
DOIs
Publication statusPublished - 22 May 2008

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