A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.

J.E. Moses, D.J. Ritson, F. Zhang, C.M. Lombardo, Shozeb Haider, N. Oldham, S. Neidle

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide–alkyne ‘click’ reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
Original languageEnglish
Pages (from-to)2926-2930
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume8(13)
Issue number13
DOIs
Publication statusPublished - 28 Jun 2010

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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  • Cite this

    Moses, J. E., Ritson, D. J., Zhang, F., Lombardo, C. M., Haider, S., Oldham, N., & Neidle, S. (2010). A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic and Biomolecular Chemistry, 8(13)(13), 2926-2930. https://doi.org/10.1039/c005055e