A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.

J.E. Moses, D.J. Ritson, F. Zhang, C.M. Lombardo, Shozeb Haider, N. Oldham, S. Neidle

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide–alkyne ‘click’ reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
Original languageEnglish
Pages (from-to)2926-2930
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume8(13)
Issue number13
DOIs
Publication statusPublished - 28 Jun 2010

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry

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