Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide–alkyne ‘click’ reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
Moses, J. E., Ritson, D. J., Zhang, F., Lombardo, C. M., Haider, S., Oldham, N., & Neidle, S. (2010). A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Organic and Biomolecular Chemistry, 8(13)(13), 2926-2930. https://doi.org/10.1039/c005055e