A Comparative Review of the Effect of Microcystin-LR on the Proteome

Richard D. Welten, Julie Meneely, Christopher Elliott

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Cyanobacterial toxins are a growing threat to human and animal welfare in many parts of the world. Microcystin-LR is the most widely studied of the cyanotoxins and has been implicated with hepatotoxicity, neuropathology, and genotoxicity. Numerous studies investigated the effect of microcystin-LR exposure on the proteome using various animal models, and together they form a large database of potential protein biomarkers. However, it is extremely difficult to establish which proteins are specifically affected by microcystin-LR, and which represent a more general toxin response. The goal of this review was to filter out inconsistently reported protein abundancy changes after microcystin-LR exposure. We explored online search engines for studies investigating the effect of microcystin-LR toxicity on the proteome. The selected studies were examined to find overlapping protein abundancy changes. The protein names, their synonyms, and relevant orthologues were used as search terms. This review has produced, for the first time, a comprehensive list of proteins whose abundancies changed in at least two proteomic studies investigating microcystin-LR toxicity in rodents and zebrafish. Proteins involved in oxidoreductase activity and cytoskeletal processes are persistently affected by microcystin-LR exposure. Several oxidative stress markers are consistently altered across multiple proteomic studies, which correlates with findings from epidemiological studies that linked chronic microcystin exposure to increased incidences of liver and colorectal cancer. This study unveils which proteins’ abundancies are consistently altered after microcystin-LR exposure and opens new doors to understanding the mechanisms behind microcystin-LR toxicity.
LanguageEnglish
JournalExposure and Health
DOIs
Publication statusPublished - 18 Feb 2019

Fingerprint

Proteome
Proteins
protein
proteomics
Toxicity
toxicity
toxin
Proteomics
Animals
animal welfare
cyanoginosin LR
effect
Search Engine
genotoxicity
Animal Welfare
Protein Databases
Oxidative stress
Zebrafish
Liver Neoplasms
rodent

Keywords

  • cyanobacteria
  • cyanotoxins
  • microcystin-LR
  • microcystins
  • proteome
  • proteomics

Cite this

@article{6b37db6f5c604515a047e1d47b9c3fad,
title = "A Comparative Review of the Effect of Microcystin-LR on the Proteome",
abstract = "Cyanobacterial toxins are a growing threat to human and animal welfare in many parts of the world. Microcystin-LR is the most widely studied of the cyanotoxins and has been implicated with hepatotoxicity, neuropathology, and genotoxicity. Numerous studies investigated the effect of microcystin-LR exposure on the proteome using various animal models, and together they form a large database of potential protein biomarkers. However, it is extremely difficult to establish which proteins are specifically affected by microcystin-LR, and which represent a more general toxin response. The goal of this review was to filter out inconsistently reported protein abundancy changes after microcystin-LR exposure. We explored online search engines for studies investigating the effect of microcystin-LR toxicity on the proteome. The selected studies were examined to find overlapping protein abundancy changes. The protein names, their synonyms, and relevant orthologues were used as search terms. This review has produced, for the first time, a comprehensive list of proteins whose abundancies changed in at least two proteomic studies investigating microcystin-LR toxicity in rodents and zebrafish. Proteins involved in oxidoreductase activity and cytoskeletal processes are persistently affected by microcystin-LR exposure. Several oxidative stress markers are consistently altered across multiple proteomic studies, which correlates with findings from epidemiological studies that linked chronic microcystin exposure to increased incidences of liver and colorectal cancer. This study unveils which proteins’ abundancies are consistently altered after microcystin-LR exposure and opens new doors to understanding the mechanisms behind microcystin-LR toxicity.",
keywords = "cyanobacteria, cyanotoxins, microcystin-LR, microcystins, proteome, proteomics",
author = "Welten, {Richard D.} and Julie Meneely and Christopher Elliott",
year = "2019",
month = "2",
day = "18",
doi = "10.1007/s12403-019-00303-1",
language = "English",
journal = "Exposure and Health",
issn = "2451-9766",
publisher = "Springer Netherlands",

}

A Comparative Review of the Effect of Microcystin-LR on the Proteome. / Welten, Richard D. ; Meneely, Julie; Elliott, Christopher.

In: Exposure and Health, 18.02.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - A Comparative Review of the Effect of Microcystin-LR on the Proteome

AU - Welten, Richard D.

AU - Meneely, Julie

AU - Elliott, Christopher

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Cyanobacterial toxins are a growing threat to human and animal welfare in many parts of the world. Microcystin-LR is the most widely studied of the cyanotoxins and has been implicated with hepatotoxicity, neuropathology, and genotoxicity. Numerous studies investigated the effect of microcystin-LR exposure on the proteome using various animal models, and together they form a large database of potential protein biomarkers. However, it is extremely difficult to establish which proteins are specifically affected by microcystin-LR, and which represent a more general toxin response. The goal of this review was to filter out inconsistently reported protein abundancy changes after microcystin-LR exposure. We explored online search engines for studies investigating the effect of microcystin-LR toxicity on the proteome. The selected studies were examined to find overlapping protein abundancy changes. The protein names, their synonyms, and relevant orthologues were used as search terms. This review has produced, for the first time, a comprehensive list of proteins whose abundancies changed in at least two proteomic studies investigating microcystin-LR toxicity in rodents and zebrafish. Proteins involved in oxidoreductase activity and cytoskeletal processes are persistently affected by microcystin-LR exposure. Several oxidative stress markers are consistently altered across multiple proteomic studies, which correlates with findings from epidemiological studies that linked chronic microcystin exposure to increased incidences of liver and colorectal cancer. This study unveils which proteins’ abundancies are consistently altered after microcystin-LR exposure and opens new doors to understanding the mechanisms behind microcystin-LR toxicity.

AB - Cyanobacterial toxins are a growing threat to human and animal welfare in many parts of the world. Microcystin-LR is the most widely studied of the cyanotoxins and has been implicated with hepatotoxicity, neuropathology, and genotoxicity. Numerous studies investigated the effect of microcystin-LR exposure on the proteome using various animal models, and together they form a large database of potential protein biomarkers. However, it is extremely difficult to establish which proteins are specifically affected by microcystin-LR, and which represent a more general toxin response. The goal of this review was to filter out inconsistently reported protein abundancy changes after microcystin-LR exposure. We explored online search engines for studies investigating the effect of microcystin-LR toxicity on the proteome. The selected studies were examined to find overlapping protein abundancy changes. The protein names, their synonyms, and relevant orthologues were used as search terms. This review has produced, for the first time, a comprehensive list of proteins whose abundancies changed in at least two proteomic studies investigating microcystin-LR toxicity in rodents and zebrafish. Proteins involved in oxidoreductase activity and cytoskeletal processes are persistently affected by microcystin-LR exposure. Several oxidative stress markers are consistently altered across multiple proteomic studies, which correlates with findings from epidemiological studies that linked chronic microcystin exposure to increased incidences of liver and colorectal cancer. This study unveils which proteins’ abundancies are consistently altered after microcystin-LR exposure and opens new doors to understanding the mechanisms behind microcystin-LR toxicity.

KW - cyanobacteria

KW - cyanotoxins

KW - microcystin-LR

KW - microcystins

KW - proteome

KW - proteomics

UR - http://www.scopus.com/inward/record.url?scp=85061692892&partnerID=8YFLogxK

U2 - 10.1007/s12403-019-00303-1

DO - 10.1007/s12403-019-00303-1

M3 - Review article

JO - Exposure and Health

T2 - Exposure and Health

JF - Exposure and Health

SN - 2451-9766

ER -