A comparison of international modelling methods to evaluate health economics of colorectal cancer screening: a systematic review protocol

Olivia Adair*, Ethna McFerran, Tracy Owen, Christine McKee, Felicity Lamrock, Mark Lawler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Colorectal cancer (CRC) is becoming an increasing health problem worldwide. However, with the help of screening, early diagnosis can reduce incidence and mortality rates. To elevate the economic burden that CRC can cause, cost-effectiveness analysis (CEA) can assist healthcare systems to make screening programmes more cost-effective and prolong survival for early-stage CRC patients. This review aims to identify different CEA modelling methods used internationally to evaluate health economics of CRC screening.

This review will systematically search electronic databases which include MEDLINE, EMBASE, Web of Science and Scopus. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidance recommendations will design the review, and the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement will be used to extract relevant data from studies retrieved. Two reviewers will screen through the evidence using the PICOS (Participant, Intervention, Comparators, Outcomes, Study Design) framework, with a third reviewer to settle any disagreements. Once data extraction and quality assessment are complete, the results will be presented qualitatively and tabulated using the CHEERS checklist.

The results obtained from the systematic review will highlight how different CRC screening programmes around the world utilise and incorporate health economic modelling methods to be more cost-effective. This information can help modellers develop CEA models which can be adapted to suit the specific screening programmes that they are evaluating.

Systematic review registration
PROSPERO CRD42022296113

Original languageEnglish
Article number14
Number of pages5
JournalSystematic Reviews
Publication statusPublished - 27 Jan 2023


  • Colorectal cancer
  • Screening
  • Cost-effectiveness analysis
  • Cost-utility
  • Cost-benefit
  • Quality-adjusted life year (QALY)
  • Life years gained
  • Incremental cost-effectiveness ratio
  • Economic evaluation
  • Health economics
  • Economics, Medical
  • Cost–benefit
  • Quality-adjusted life years
  • Early Detection of Cancer - methods
  • Humans
  • Colorectal Neoplasms - diagnosis - epidemiology
  • Delivery of Health Care
  • Cost-Benefit Analysis
  • Systematic Reviews as Topic


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