A concise and convergent (formal) total synthesis of huperzine A

John Mann; C. Lucey; S. Kelly

doi:10.1039/b615059d

A concise and convergent (formal) total synthesis of huperzine A

John Mann, C. Lucey, S. Kelly

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsillyoxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl)methylcyclohex-2-enol.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	5(2)
Issue number	2
DOIs	https://doi.org/10.1039/b615059d
Publication status	Published - Jan 2007

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
General Chemistry

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10.1039/b615059d

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title = "A concise and convergent (formal) total synthesis of huperzine A",

abstract = "The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsillyoxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl)methylcyclohex-2-enol.",

author = "John Mann and C. Lucey and S. Kelly",

year = "2007",

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AU - Lucey, C.

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AB - The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsillyoxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl)methylcyclohex-2-enol.

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DO - 10.1039/b615059d

M3 - Article

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 2

ER -

A concise and convergent (formal) total synthesis of huperzine A

Abstract

ASJC Scopus subject areas

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