Abstract
The silicone elastomer solubilities of a range of drugs and pharmaceutical excipients employed in the development of silicone intravaginal drug delivery rings (polyethylene glycols, norethisterone acetate, estradiol, triclosan, oleyl alcohol, oxybutynin) have been determined using dynamic mechanical analysis. The method involves measuring the concentration-dependent decrease in the storage modulus associated with the melting of the incorporated drug/excipient, and extrapolation to zero change in storage modulus. The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices at 37°C.
Original language | English |
---|---|
Pages (from-to) | 3589-3594 |
Number of pages | 6 |
Journal | Biomaterials |
Volume | 23 |
Issue number | 17 |
DOIs | |
Publication status | Published - 01 Jan 2002 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Fingerprint
Dive into the research topics of 'A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings'. Together they form a unique fingerprint.Impacts
-
Protecting Women from HIV AIDS: Dapivirine Vaginal Ring HIV Microbicide
David Woolfson (Participant), Karl Malcolm (Participant), Stephen McCullagh (Participant) & Martin Catney (Participant)
Impact: Health Impact