A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings

R.K. Malcolm, S. McCullagh, M. Catney, P. Tallon, David Woolfson

Research output: Contribution to journalArticle

22 Citations (Scopus)
56 Downloads (Pure)

Abstract

The silicone elastomer solubilities of a range of drugs and pharmaceutical excipients employed in the development of silicone intravaginal drug delivery rings (polyethylene glycols, norethisterone acetate, estradiol, triclosan, oleyl alcohol, oxybutynin) have been determined using dynamic mechanical analysis. The method involves measuring the concentration-dependent decrease in the storage modulus associated with the melting of the incorporated drug/excipient, and extrapolation to zero change in storage modulus. The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices at 37°C.
Original languageEnglish
Pages (from-to)3589-3594
Number of pages6
JournalBiomaterials
Volume23
Issue number17
DOIs
Publication statusPublished - 01 Jan 2002

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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