A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings

R.K. Malcolm; S. McCullagh; M. Catney; P. Tallon; David Woolfson

doi:10.1016/S0142-9612(02)00086-8

A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings

R.K. Malcolm, S. McCullagh, M. Catney, P. Tallon, David Woolfson

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28 Citations (Scopus)

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Abstract

The silicone elastomer solubilities of a range of drugs and pharmaceutical excipients employed in the development of silicone intravaginal drug delivery rings (polyethylene glycols, norethisterone acetate, estradiol, triclosan, oleyl alcohol, oxybutynin) have been determined using dynamic mechanical analysis. The method involves measuring the concentration-dependent decrease in the storage modulus associated with the melting of the incorporated drug/excipient, and extrapolation to zero change in storage modulus. The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices at 37°C.

Original language	English
Pages (from-to)	3589-3594
Number of pages	6
Journal	Biomaterials
Volume	23
Issue number	17
DOIs	https://doi.org/10.1016/S0142-9612(02)00086-8
Publication status	Published - 01 Jan 2002

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/S0142-9612(02)00086-8

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abstract = "The silicone elastomer solubilities of a range of drugs and pharmaceutical excipients employed in the development of silicone intravaginal drug delivery rings (polyethylene glycols, norethisterone acetate, estradiol, triclosan, oleyl alcohol, oxybutynin) have been determined using dynamic mechanical analysis. The method involves measuring the concentration-dependent decrease in the storage modulus associated with the melting of the incorporated drug/excipient, and extrapolation to zero change in storage modulus. The study also demonstrates the effect of drug/excipient concentrations on the mechanical stiffness of the silicone devices at 37°C. ",

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AU - Tallon, P.

AU - Woolfson, David

PY - 2002/1/1

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JO - Biomaterials

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A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings

Abstract

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Protecting Women from HIV AIDS: Dapivirine Vaginal Ring HIV Microbicide

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A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings

Abstract

ASJC Scopus subject areas

Access to Document

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Protecting Women from HIV AIDS: Dapivirine Vaginal Ring HIV Microbicide

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