A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

Stephen J. McMahon*, Karl T. Butterworth, Colman Trainor, Conor K. McGarry, Joe M. O'Sullivan, Giuseppe Schettino, Alan R. Hounsell, Kevin M. Prise

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Citations (Scopus)
148 Downloads (Pure)

Abstract

It is now widely accepted that intercellular communication can cause significant variations in cellular responses to genotoxic stress. The radiation-induced bystander effect is a prime example of this effect, where cells shielded from radiation exposure see a significant reduction in survival when cultured with irradiated cells. However, there is a lack of robust, quantitative models of this effect which are widely applicable. In this work, we present a novel mathematical model of radiation-induced intercellular signalling which incorporates signal production and response kinetics together with the effects of direct irradiation, and test it against published data sets, including modulated field exposures. This model suggests that these so-called "bystander" effects play a significant role in determining cellular survival, even in directly irradiated populations, meaning that the inclusion of intercellular communication may be essential to produce robust models of radio-biological outcomes in clinically relevant in vivo situations.
Original languageEnglish
Article numbere54526
Number of pages12
JournalPloS one
Volume8
Issue number1
DOIs
Publication statusPublished - 22 Jan 2013

Keywords

  • DOUBLE-STRAND BREAKS
  • X-RAYS
  • CELLULAR-RESPONSE
  • BYSTANDER
  • CELLS
  • FIELDS
  • IRRADIATION
  • SURVIVAL
  • INDUCTION
  • TISSUES

Fingerprint Dive into the research topics of 'A Kinetic-Based Model of Radiation-Induced Intercellular Signalling'. Together they form a unique fingerprint.

  • Cite this