A literature review of end-stage renal disease and cachexia: Understanding experience to inform evidence-based healthcare

Joanne Reid, Helen Rose Noble, Sam Porter, Joanne Sarah Shields, Alexander Peter Maxwell

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7 Citations (Scopus)



Cachexia is a major cause of morbidity and mortality in people who have end-stage renal disease (ESRD). The majority of research into cachexia in ESRD has focused on the biological aspects of the syndrome and potential treatment modalities. While this research is necessary, it predominately focuses on the physical impact of cachexia in ESRD. The multi-dimensional psychosocial ramifications of this syndrome have been highlighted in other end-stage illness trajectories, but have not been systematically explored in persons who have ESRD.


This paper discusses why this research is necessary, alongside further studies to help define the pathophysiology of this syndrome.


The rich insightful data gained from understanding the patients' illness experience will positively contribute to the limited knowledge base available and inform future holistic patient-centred care delivery which recognises and responds to not only the biological but also the psychosocial impact of cachexia.
Original languageEnglish
Pages (from-to)47-51
JournalJournal of Renal Care
Issue number1
Early online date25 Feb 2013
Publication statusPublished - Mar 2013


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IF: 0.305

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