A mapper-based classifier for patient subgroup prediction

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Mapper algorithm serves as a valuable tool for constructing graph-based representations of high-dimensional data, capturing both topological and geometric information at a specified resolution. This approach has found successful applications in patient subgroup discovery, offering valuable insights from diverse biomedical datasets. Subgroup discovery seeks to identify homogeneous patient subsets within large,heterogeneous cohorts, ultimately enabling more personalized and effective treatment strategies on an individual patient level. The discovery of new subgroups becomes even more beneficial when we possess an effective method for determining whether anew patient should be classified as a member of a particular subgroup or not. While machine learning methods have proven their utility in various subgroup classification tasks across different medical applications, our experimental evaluations across multiple medical datasets have revealed their challenges in learning patterns associated with small regions of a Mapper graph, resulting in low classification accuracy. To address this issue, we propose a hypothesis that the prediction of subgroups detected via the Mapper graph should rely on Mapper graph-based distances. Consequently, in this study, we introduce a novel approach called the Mapper k Nearest Neighbor algorithm for performing subgroup classification on a Mapper graph. We substantiate the effectiveness of our method through experiments conducted on five real-life gene expression cancer datasets.
Original languageEnglish
Title of host publication2023 International Conference on e-Health and Bioengineering (EHB): proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Publication statusAccepted - 09 Aug 2023
Event11th International Conference on e-Health and Bioengineering - Romania, Bucharest, Romania
Duration: 09 Nov 202310 Nov 2023
http://www.ehbconference.ro/Home.aspx

Publication series

NameInternational Conference on e-Health and Bioengineering (EHB): proceedings
PublisherIEEE
ISSN (Print)2575-5137
ISSN (Electronic)2575-5145

Conference

Conference11th International Conference on e-Health and Bioengineering
Abbreviated titleEHB 2023
Country/TerritoryRomania
CityBucharest
Period09/11/202310/11/2023
Internet address

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