A Mild New Method for the C-Acylation of Ketone Enolates. A Convenient Synthesis of β-Keto Esters, -Thionoesters and Thioesters

Karl J. Hale, Milosz Grabski, Jakub T. Flasz

Research output: Contribution to journalLetter

10 Citations (Scopus)

Abstract

Abstract image.

A new method for ketone enolate C-acylation is described which utilizes alkyl pentafluorophenylcarbonates, thiocarbonates and thionocarbonates as the reactive acylating agents, and MgBr2.Et2O, DMAP and i-Pr2NEt as the reagents for enolization. A wide range of ketones have been observed to undergo clean C-acylation via this protocol.
Original languageEnglish
Pages (from-to)370-373
Number of pages4
JournalOrganic Letters
Volume15
Issue number2
Early online date31 Dec 2012
DOIs
Publication statusPublished - 2013

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