A new class of membrane-bound chemokine with a CX3C motif

J. Fernando Bazan, Kevin B. Bacon, Gary Hardiman, Wei Wang, Ken Soo, Devora Rossi, David R. Greaves, Albert Zlotnik, Thomas J. Schall*

*Corresponding author for this work

Research output: Contribution to journalArticle

1586 Citations (Scopus)

Abstract

Chemokines direct the trafficking of white blood cells in immune surveillance, playing a key role in inflammatory and infectious diseases such as AIDS. All chemokines studied so far are secreted proteins of relative molecular mass ~7K-15K and fall into three families that are defined by a cysteine signature motif: CXC, CC and C, where C is a cysteine and X any amino-acid residue. We report here the identification and characterization of a fourth human chemokine type, derived from non-haemopoietic cells and bearing a new CX3C fingerprint. Unlike other chemokine types, the polypeptide chain of the human CX3C chemokine is predicted to be part of a 373-amino-acid protein that carries the chemokine domain on top of an extended mucin-like stalk. This molecule can exist in two forms: either membrane-anchored or as a shed 95K glycoprotein. The soluble CX3C chemokine has potent chemoattractant activity for T cells and monocytes, and the cell- surface-bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokine that may constitute part of the molecular control of leukocyte traffic at the endothelium.

Original languageEnglish
Pages (from-to)640-642
Number of pages3
JournalNature
Volume385
Issue number6617
DOIs
Publication statusPublished - 13 Feb 1997
Externally publishedYes

ASJC Scopus subject areas

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    Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997). A new class of membrane-bound chemokine with a CX3C motif. Nature, 385(6617), 640-642. https://doi.org/10.1038/385640a0