Abstract
Cancer prediction models provide an important approach to assess risk and prognosis by identifying individuals and enabling estimates of the population burden and cost of cancer. Models also may aid in the evaluation of treatments and interventions. A number of statistical and machine learning techniques have been employed to develop various cancer prediction models. Meanwhile, gene selection is very important for cancer classification. We need to deal with high-dimensional gene space and few samples. But the epistasis means that some genes maybe cover or affect other genes. Fuzzy measure can describe the interaction between genes very well. In this article, we proposed one new model based on fuzzy integral with respect to fuzzy measure for cancer prediction with sparse genes. We can obtain a group of combinations of genes with the highest fuzzy measure values. The new method is applied to two cancer data for testifying the performance. Experimental results show that the proposed model has the highest testing accuracy and F-score by comparing with several state-of-the-art methods.
Original language | English |
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Title of host publication | Proceedings -2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) |
Editors | Harald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 2309-2315 |
Number of pages | 7 |
ISBN (Electronic) | 9781538654880 |
ISBN (Print) | 9781538654897 |
DOIs | |
Publication status | Published - 24 Jan 2019 |
Externally published | Yes |
Event | 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain Duration: 03 Dec 2018 → 06 Dec 2018 |
Publication series
Name | Proceedings - IEEE International Conference on Bioinformatics and Biomedicine (BIBM) |
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Conference
Conference | 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 |
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Country/Territory | Spain |
City | Madrid |
Period | 03/12/2018 → 06/12/2018 |
Bibliographical note
Funding Information:This work is supported by the EU Horizon 2020 (No.: 690238), the Technology Planning Project of Guangdong Province (No.: 2017A040406023) and the Technology Planning Project of Guangzho City (No.: 201804010353). *corresponding author
Publisher Copyright:
© 2018 IEEE.
Keywords
- Cancer prediction
- Fuzzy measure
- Gene selection
ASJC Scopus subject areas
- Biomedical Engineering
- Health Informatics