A new perspective on lipid research in age-related macular degeneration

Elisabeth M van Leeuwen; Eszter Emri; Benedicte M J Merle; Johanna M Colijn; Eveline Kersten; Audrey Cougnard-Gregoire; Sascha Dammeier; Magda Meester-Smoor; Frances M Pool; Eiko K de Jong; Cécile Delcourt; Eduardo Rodrigez-Bocanegra; Marc Biarnés; Philip J Luthert; Marius Ueffing; Caroline C W Klaver; Everson Nogoceke; Anneke I den Hollander; Imre Lengyel

doi:10.1016/j.preteyeres.2018.04.006

A new perspective on lipid research in age-related macular degeneration

Elisabeth M van Leeuwen, Eszter Emri, Benedicte M J Merle, Johanna M Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M Pool, Eiko K de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J Luthert, Marius Ueffing, Caroline C W Klaver, Everson Nogoceke, Anneke I den Hollander, Imre Lengyel

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

165 Downloads (Pure)

Abstract

There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.

Original language	English
Pages (from-to)	1-31
Journal	Progress in Retinal and Eye Research
Early online date	03 May 2018
DOIs	https://doi.org/10.1016/j.preteyeres.2018.04.006
Publication status	Early online date - 03 May 2018
Externally published	Yes

Keywords

Journal Article
Review

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10.1016/j.preteyeres.2018.04.006Licence: CC BY-NC-ND

A new perspective on lipid research in age-related macular degeneration
Copyright 2018 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 2.7 MBLicence: CC BY

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Imre Lengyel
- i.lengyel@qub.ac.uk
- School of Medicine, Dentistry and Biomedical Sciences - Senior Lecturer
- Wellcome Wolfson Institute for Experimental Medicine
Person: Academic

Cite this

van Leeuwen, E. M., Emri, E., Merle, B. M. J., Colijn, J. M., Kersten, E., Cougnard-Gregoire, A., Dammeier, S., Meester-Smoor, M., Pool, F. M., de Jong, E. K., Delcourt, C., Rodrigez-Bocanegra, E., Biarnés, M., Luthert, P. J., Ueffing, M., Klaver, C. C. W., Nogoceke, E., den Hollander, A. I., & Lengyel, I. (2018). A new perspective on lipid research in age-related macular degeneration. Progress in Retinal and Eye Research, 1-31. https://doi.org/10.1016/j.preteyeres.2018.04.006

van Leeuwen, Elisabeth M ; Emri, Eszter ; Merle, Benedicte M J ; Colijn, Johanna M ; Kersten, Eveline ; Cougnard-Gregoire, Audrey ; Dammeier, Sascha ; Meester-Smoor, Magda ; Pool, Frances M ; de Jong, Eiko K ; Delcourt, Cécile ; Rodrigez-Bocanegra, Eduardo ; Biarnés, Marc ; Luthert, Philip J ; Ueffing, Marius ; Klaver, Caroline C W ; Nogoceke, Everson ; den Hollander, Anneke I ; Lengyel, Imre. / A new perspective on lipid research in age-related macular degeneration. In: Progress in Retinal and Eye Research. 2018 ; pp. 1-31.

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abstract = "There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.",

keywords = "Journal Article, Review",

author = "{van Leeuwen}, {Elisabeth M} and Eszter Emri and Merle, {Benedicte M J} and Colijn, {Johanna M} and Eveline Kersten and Audrey Cougnard-Gregoire and Sascha Dammeier and Magda Meester-Smoor and Pool, {Frances M} and {de Jong}, {Eiko K} and C{\'e}cile Delcourt and Eduardo Rodrigez-Bocanegra and Marc Biarn{\'e}s and Luthert, {Philip J} and Marius Ueffing and Klaver, {Caroline C W} and Everson Nogoceke and {den Hollander}, {Anneke I} and Imre Lengyel",

note = "Copyright {\textcopyright} 2018. Published by Elsevier Ltd.",

year = "2018",

month = may,

day = "3",

doi = "10.1016/j.preteyeres.2018.04.006",

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van Leeuwen, EM, Emri, E, Merle, BMJ, Colijn, JM, Kersten, E, Cougnard-Gregoire, A, Dammeier, S, Meester-Smoor, M, Pool, FM, de Jong, EK, Delcourt, C, Rodrigez-Bocanegra, E, Biarnés, M, Luthert, PJ, Ueffing, M, Klaver, CCW, Nogoceke, E, den Hollander, AI & Lengyel, I 2018, 'A new perspective on lipid research in age-related macular degeneration', Progress in Retinal and Eye Research, pp. 1-31. https://doi.org/10.1016/j.preteyeres.2018.04.006

A new perspective on lipid research in age-related macular degeneration. / van Leeuwen, Elisabeth M; Emri, Eszter; Merle, Benedicte M J; Colijn, Johanna M; Kersten, Eveline; Cougnard-Gregoire, Audrey; Dammeier, Sascha; Meester-Smoor, Magda; Pool, Frances M; de Jong, Eiko K; Delcourt, Cécile; Rodrigez-Bocanegra, Eduardo; Biarnés, Marc; Luthert, Philip J; Ueffing, Marius; Klaver, Caroline C W; Nogoceke, Everson; den Hollander, Anneke I; Lengyel, Imre.

In: Progress in Retinal and Eye Research, 03.05.2018, p. 1-31.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - A new perspective on lipid research in age-related macular degeneration

AU - van Leeuwen, Elisabeth M

AU - Emri, Eszter

AU - Merle, Benedicte M J

AU - Colijn, Johanna M

AU - Kersten, Eveline

AU - Cougnard-Gregoire, Audrey

AU - Dammeier, Sascha

AU - Meester-Smoor, Magda

AU - Pool, Frances M

AU - de Jong, Eiko K

AU - Delcourt, Cécile

AU - Rodrigez-Bocanegra, Eduardo

AU - Biarnés, Marc

AU - Luthert, Philip J

AU - Ueffing, Marius

AU - Klaver, Caroline C W

AU - Nogoceke, Everson

AU - den Hollander, Anneke I

AU - Lengyel, Imre

PY - 2018/5/3

Y1 - 2018/5/3

N2 - There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.

AB - There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.

KW - Journal Article

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DO - 10.1016/j.preteyeres.2018.04.006

M3 - Review article

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JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

SN - 1350-9462

ER -