TY - JOUR
T1 - A new perspective on lipid research in age-related macular degeneration
AU - van Leeuwen, Elisabeth M
AU - Emri, Eszter
AU - Merle, Benedicte M J
AU - Colijn, Johanna M
AU - Kersten, Eveline
AU - Cougnard-Gregoire, Audrey
AU - Dammeier, Sascha
AU - Meester-Smoor, Magda
AU - Pool, Frances M
AU - de Jong, Eiko K
AU - Delcourt, Cécile
AU - Rodrigez-Bocanegra, Eduardo
AU - Biarnés, Marc
AU - Luthert, Philip J
AU - Ueffing, Marius
AU - Klaver, Caroline C W
AU - Nogoceke, Everson
AU - den Hollander, Anneke I
AU - Lengyel, Imre
N1 - Copyright © 2018. Published by Elsevier Ltd.
PY - 2018/5/3
Y1 - 2018/5/3
N2 - There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.
AB - There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.
KW - Journal Article
KW - Review
U2 - 10.1016/j.preteyeres.2018.04.006
DO - 10.1016/j.preteyeres.2018.04.006
M3 - Review article
C2 - 29729972
SP - 1
EP - 31
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
SN - 1350-9462
ER -