A new perspective on lipid research in age-related macular degeneration

Elisabeth M van Leeuwen, Eszter Emri, Benedicte M J Merle, Johanna M Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M Pool, Eiko K de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J Luthert, Marius Ueffing, Caroline C W Klaver, Everson Nogoceke, Anneke I den Hollander, Imre Lengyel

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)
165 Downloads (Pure)

Abstract

There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.

Original languageEnglish
Pages (from-to)1-31
JournalProgress in Retinal and Eye Research
Early online date03 May 2018
DOIs
Publication statusEarly online date - 03 May 2018
Externally publishedYes

Keywords

  • Journal Article
  • Review

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