A nitrile-metabolising enzyme and a process for producing an acid using same

Lee Coffey (Inventor), Catherine O'Reilly (Inventor), Claire Lennon (Inventor), Tracey Coady (Inventor), Erica Owens (Inventor), Panagiotis Manesiotis (Inventor), Karen Tambling (Inventor)

Research output: Patent

Abstract

The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the nitrile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention extends to a process for producing a carboxylic acid using said isolated polypeptide to metabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.
Original languageEnglish
Patent numberWO2013004834 A1
Publication statusPublished - 10 Jan 2013

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Nitriles
nitrilase
Carboxylic Acids
Peptides
Acids
Enzymes
Pantoea

Cite this

Coffey, L., O'Reilly, C., Lennon, C., Coady, T., Owens, E., Manesiotis, P., & Tambling, K. (2013). A nitrile-metabolising enzyme and a process for producing an acid using same. (Patent No. WO2013004834 A1).
Coffey, Lee (Inventor) ; O'Reilly, Catherine (Inventor) ; Lennon, Claire (Inventor) ; Coady, Tracey (Inventor) ; Owens, Erica (Inventor) ; Manesiotis, Panagiotis (Inventor) ; Tambling, Karen (Inventor). / A nitrile-metabolising enzyme and a process for producing an acid using same. Patent No.: WO2013004834 A1.
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abstract = "The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the nitrile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention extends to a process for producing a carboxylic acid using said isolated polypeptide to metabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.",
author = "Lee Coffey and Catherine O'Reilly and Claire Lennon and Tracey Coady and Erica Owens and Panagiotis Manesiotis and Karen Tambling",
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Coffey, L, O'Reilly, C, Lennon, C, Coady, T, Owens, E, Manesiotis, P & Tambling, K 2013, A nitrile-metabolising enzyme and a process for producing an acid using same, Patent No. WO2013004834 A1.

A nitrile-metabolising enzyme and a process for producing an acid using same. / Coffey, Lee (Inventor); O'Reilly, Catherine (Inventor); Lennon, Claire (Inventor); Coady, Tracey (Inventor); Owens, Erica (Inventor); Manesiotis, Panagiotis (Inventor); Tambling, Karen (Inventor).

Patent No.: WO2013004834 A1.

Research output: Patent

TY - PAT

T1 - A nitrile-metabolising enzyme and a process for producing an acid using same

AU - Coffey, Lee

AU - O'Reilly, Catherine

AU - Lennon, Claire

AU - Coady, Tracey

AU - Owens, Erica

AU - Manesiotis, Panagiotis

AU - Tambling, Karen

PY - 2013/1/10

Y1 - 2013/1/10

N2 - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the nitrile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention extends to a process for producing a carboxylic acid using said isolated polypeptide to metabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.

AB - The present invention relates to an isolated nucleotide sequence and corresponding polypeptide derived from the nitrile-metabolising Pantoea strain deposited under NCIMB 41854. Said isolated polypeptide acts as a nitrilase and the invention extends to a process for producing a carboxylic acid using said isolated polypeptide to metabolise nitriles such as 3-hydroxyglutaronitrile, 3-hydroxybutyronitrile and 3- hydroxy-phenylpropionitrile to form corresponding carboxylic acids.

M3 - Patent

M1 - WO2013004834 A1

ER -

Coffey L, O'Reilly C, Lennon C, Coady T, Owens E, Manesiotis P et al, inventors. A nitrile-metabolising enzyme and a process for producing an acid using same. WO2013004834 A1. 2013 Jan 10.