A novel and effective hyperthermia method for Schistosomiasis japonica prevention and treatment

Huixia Yang, Tao Tang, Pei He, Youren Zhang, Le Xie, Guangqi Liu, Li Li, Weichao Kong, Jingdingsha Li, Ruiting Liu, Yukun Li, Junjian Hu, Xiaowen Wang, Liya Li, Guanghong Xiang, Geoffrey Gobert, Yuesheng Li, Jintian Tang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 % (37 °C, 5 min) to 0 (49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy (P < 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for 5 min within 8 h of infection, worm reduction rate (WRR) reached 74 %–83 % (P < 0.01). The sensitivity of adult schistosoma to heat was also investigated using microwave intraperitoneal hyperthermia (thermal dosages 42–43 °C, 20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel (PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus, hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.

Original languageEnglish
Pages (from-to)1461-1464
Number of pages4
JournalChinese Science Bulletin
Issue number16
Early online date22 Aug 2015
Publication statusPublished - Aug 2015
Externally publishedYes


  • Cercariae
  • Hyperthermia
  • Praziquantel (PZQ)
  • Schistosomiasis japonica

ASJC Scopus subject areas

  • General


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