TY - GEN
T1 - A novel cellular automata modelling framework for micro-environmental interaction and co-invasion
AU - Hodgkinson, A
PY - 2018/8/26
Y1 - 2018/8/26
N2 - Modern biological paradigms of invasion in tumour cells cannot be fully explained or described by existing modelling techniques. We present a novel cellular automata model which represents both the nucleus of a cell and its membrane, allowing one to capture the interaction of a cell with its environment, as well as selected theorems for the efficient computation of solutions to such systems. We use this technique to simulate cell-cell binding, single-cellular micro track invasion, and co-injection of MITFhigh (proliferative) and MITFlow (invasive) tumour cells into heterogeneous environments. Results shed new light on emergent phenomena of cellular elongation, filopodial protrusion, and the co-invasion of the local stroma by classically non-invasive cells. We also provide a new modelling framework in which the cellular automaton exhibits non-local interaction within its context.
AB - Modern biological paradigms of invasion in tumour cells cannot be fully explained or described by existing modelling techniques. We present a novel cellular automata model which represents both the nucleus of a cell and its membrane, allowing one to capture the interaction of a cell with its environment, as well as selected theorems for the efficient computation of solutions to such systems. We use this technique to simulate cell-cell binding, single-cellular micro track invasion, and co-injection of MITFhigh (proliferative) and MITFlow (invasive) tumour cells into heterogeneous environments. Results shed new light on emergent phenomena of cellular elongation, filopodial protrusion, and the co-invasion of the local stroma by classically non-invasive cells. We also provide a new modelling framework in which the cellular automaton exhibits non-local interaction within its context.
U2 - 10.1007/978-3-319-99813-8_3
DO - 10.1007/978-3-319-99813-8_3
M3 - Conference contribution
SN - 9783319998121
T3 - Lecture Notes in Computer Science
SP - 30
EP - 41
BT - Cellular Automata: 13th International Conference on Cellular Automata for Research and Industry, ACRI 2018: Proceedings
A2 - Mauri, Giancarlo
A2 - El Yacoubi, Samira
A2 - Dennunzio, Alberto
A2 - Nishinari, Katsuhiro
A2 - Manzoni, Luca
PB - Springer
T2 - 13th International Conference on Cellular Automata for Research and Industry, ACRI 2018
Y2 - 17 September 2018 through 21 September 2018
ER -