A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources

Chris Polin; Nathan Wardlow; Harold McQuaid; Philip Orr; Balder Villagomez-Bernabe; Catarina Figueira; Grace Alexander; Shajeth Srigengan; Emilie Brun; Manon Gilles; Cécile Sicard-Roselli; Fred J. Currell

doi:10.1063/1.4914054

A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources

Chris Polin, Nathan Wardlow, Harold McQuaid, Philip Orr, Balder Villagomez-Bernabe, Catarina Figueira, Grace Alexander, Shajeth Srigengan, Emilie Brun, Manon Gilles, Cécile Sicard-Roselli, Fred J. Currell

Research output: Contribution to journal › Article › peer-review

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Abstract

Here is detailed a novel and low-cost experimental method for high-throughput automated fluid sample irradiation. The sample is delivered via syringe pump to a nozzle, where it is expressed in the form of a hanging droplet into the path of a beam of ionising radiation. The dose delivery is controlled by an upstream lead shutter, which allows the beam to reach the droplet for a user defined period of time. The droplet is then further expressed after irradiation until it falls into one well of a standard microplate. The entire system is automated and can be operated remotely using software designed in-house, allowing for use in environments deemed unsafe for the user (synchrotron beamlines, for example). Depending on the number of wells in the microplate, several droplets can be irradiated before any human interaction is necessary, and the user may choose up to 10 samples per microplate using an array of identical syringe pumps, the design of which is described here. The nozzles consistently produce droplets of 25.1 ± 0.5 μl.

Original language	English
Article number	035106
Journal	Review of Scientific Instruments
Volume	86
Issue number	3
DOIs	https://doi.org/10.1063/1.4914054
Publication status	Published - Mar 2015

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10.1063/1.4914054

A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources
© 2015 AIP Publishing LLC. Reprinted with permission from Review of Scientific Instruments, American Institute of Physics.
Accepted author manuscript, 818 KB

Tissue-equivalent and nanoparticle doped resin dosimeters
Figueira, C. (Author), Currell, F. (Supervisor) & Greenwood, J. (Supervisor), Jul 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy

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Polin, C., Wardlow, N., McQuaid, H., Orr, P., Villagomez-Bernabe, B., Figueira, C., Alexander, G., Srigengan, S., Brun, E., Gilles, M., Sicard-Roselli, C., & Currell, F. J. (2015). A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources. Review of Scientific Instruments, 86(3), Article 035106. https://doi.org/10.1063/1.4914054

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title = "A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources",

abstract = "Here is detailed a novel and low-cost experimental method for high-throughput automated fluid sample irradiation. The sample is delivered via syringe pump to a nozzle, where it is expressed in the form of a hanging droplet into the path of a beam of ionising radiation. The dose delivery is controlled by an upstream lead shutter, which allows the beam to reach the droplet for a user defined period of time. The droplet is then further expressed after irradiation until it falls into one well of a standard microplate. The entire system is automated and can be operated remotely using software designed in-house, allowing for use in environments deemed unsafe for the user (synchrotron beamlines, for example). Depending on the number of wells in the microplate, several droplets can be irradiated before any human interaction is necessary, and the user may choose up to 10 samples per microplate using an array of identical syringe pumps, the design of which is described here. The nozzles consistently produce droplets of 25.1 ± 0.5 μl.",

author = "Chris Polin and Nathan Wardlow and Harold McQuaid and Philip Orr and Balder Villagomez-Bernabe and Catarina Figueira and Grace Alexander and Shajeth Srigengan and Emilie Brun and Manon Gilles and C{\'e}cile Sicard-Roselli and Currell, {Fred J.}",

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doi = "10.1063/1.4914054",

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Polin, C, Wardlow, N, McQuaid, H, Orr, P, Villagomez-Bernabe, B, Figueira, C, Alexander, G, Srigengan, S, Brun, E, Gilles, M, Sicard-Roselli, C & Currell, FJ 2015, 'A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources', Review of Scientific Instruments, vol. 86, no. 3, 035106. https://doi.org/10.1063/1.4914054

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AU - Wardlow, Nathan

AU - McQuaid, Harold

AU - Orr, Philip

AU - Villagomez-Bernabe, Balder

AU - Figueira, Catarina

AU - Alexander, Grace

AU - Srigengan, Shajeth

AU - Brun, Emilie

AU - Gilles, Manon

AU - Sicard-Roselli, Cécile

AU - Currell, Fred J.

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N2 - Here is detailed a novel and low-cost experimental method for high-throughput automated fluid sample irradiation. The sample is delivered via syringe pump to a nozzle, where it is expressed in the form of a hanging droplet into the path of a beam of ionising radiation. The dose delivery is controlled by an upstream lead shutter, which allows the beam to reach the droplet for a user defined period of time. The droplet is then further expressed after irradiation until it falls into one well of a standard microplate. The entire system is automated and can be operated remotely using software designed in-house, allowing for use in environments deemed unsafe for the user (synchrotron beamlines, for example). Depending on the number of wells in the microplate, several droplets can be irradiated before any human interaction is necessary, and the user may choose up to 10 samples per microplate using an array of identical syringe pumps, the design of which is described here. The nozzles consistently produce droplets of 25.1 ± 0.5 μl.

AB - Here is detailed a novel and low-cost experimental method for high-throughput automated fluid sample irradiation. The sample is delivered via syringe pump to a nozzle, where it is expressed in the form of a hanging droplet into the path of a beam of ionising radiation. The dose delivery is controlled by an upstream lead shutter, which allows the beam to reach the droplet for a user defined period of time. The droplet is then further expressed after irradiation until it falls into one well of a standard microplate. The entire system is automated and can be operated remotely using software designed in-house, allowing for use in environments deemed unsafe for the user (synchrotron beamlines, for example). Depending on the number of wells in the microplate, several droplets can be irradiated before any human interaction is necessary, and the user may choose up to 10 samples per microplate using an array of identical syringe pumps, the design of which is described here. The nozzles consistently produce droplets of 25.1 ± 0.5 μl.

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A novel experimental approach to investigate radiolysis processes in liquid samples using collimated radiation sources

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Tissue-equivalent and nanoparticle doped resin dosimeters

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