A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity

R E Straub, C J MacLean, F A O'Neill, J Burke, B Murphy, F Duke, R Shinkwin, B T Webb, J Zhang, D Walsh

Research output: Contribution to journalArticlepeer-review

389 Citations (Scopus)

Abstract

In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.
Original languageEnglish
Pages (from-to)287-93
Number of pages7
JournalNature Genetics
Volume11
Issue number3
DOIs
Publication statusPublished - Nov 1995

Keywords

  • Chromosomes, Human, Pair 6
  • Genetic Heterogeneity
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Lod Score
  • Models, Genetic
  • Pedigree
  • Schizophrenia

Fingerprint Dive into the research topics of 'A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity'. Together they form a unique fingerprint.

Cite this