A primer on the current state of microarray technologies

Alexander J. Trachtenberg; Jae Hyung Robert; Azza E. Abdalla; Andrew Fraser; Steven Y. He; Jessica N. Lacy; Chiara Rivas-Morello; Allison Truong; Gary Hardiman; Lucila Ohno-Machado; Fang Liu; Eivind Hovig; Winston Patrick Kuo

doi:10.1007/978-1-61779-400-1_1

A primer on the current state of microarray technologies

Alexander J. Trachtenberg, Jae Hyung Robert, Azza E. Abdalla, Andrew Fraser, Steven Y. He, Jessica N. Lacy, Chiara Rivas-Morello, Allison Truong, Gary Hardiman, Lucila Ohno-Machado, Fang Liu, Eivind Hovig, Winston Patrick Kuo^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

12 Citations (Scopus)

Abstract

DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science analyses on massive levels. The availability of microarrays permit the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis, improved drug development, and therapeutics tailored to specific disease processes. In this chapter, we provide an overview on the current state of common microarray technologies and platforms. Since many genes contribute to normal functioning, research efforts are moving from the search for a disease-specific gene to the understanding of the biochemical and molecular functioning of a variety of genes whose disrupted interaction in complicated networks can lead to a disease state. The field of microarrays has evolved over the past decade and is now standardized with a high level of quality control, while providing a relatively inexpensive and reliable alternative to studying various aspects of gene expression.

Original language	English
Title of host publication	Next Generation Microarray Bioinformatics
Subtitle of host publication	Methods and Protocols
Editors	Junbai Wang, Tianhai Tian, Aik Choon Tan
Pages	3-17
Number of pages	15
DOIs	https://doi.org/10.1007/978-1-61779-400-1_1
Publication status	Published - 02 Jan 2012
Externally published	Yes

Publication series

Name	Methods in Molecular Biology
Volume	802
ISSN (Print)	1064-3745

Keywords

Cross platform
Gene expression
High throughput
Microarrays
One dye
QRT-PCR
Two dye

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/978-1-61779-400-1_1

Cite this

Trachtenberg, A. J., Robert, J. H., Abdalla, A. E., Fraser, A., He, S. Y., Lacy, J. N., Rivas-Morello, C., Truong, A., Hardiman, G., Ohno-Machado, L., Liu, F., Hovig, E., & Kuo, W. P. (2012). A primer on the current state of microarray technologies. In J. Wang, T. Tian, & A. C. Tan (Eds.), Next Generation Microarray Bioinformatics: Methods and Protocols (pp. 3-17). (Methods in Molecular Biology; Vol. 802). https://doi.org/10.1007/978-1-61779-400-1_1

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abstract = "DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science analyses on massive levels. The availability of microarrays permit the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis, improved drug development, and therapeutics tailored to specific disease processes. In this chapter, we provide an overview on the current state of common microarray technologies and platforms. Since many genes contribute to normal functioning, research efforts are moving from the search for a disease-specific gene to the understanding of the biochemical and molecular functioning of a variety of genes whose disrupted interaction in complicated networks can lead to a disease state. The field of microarrays has evolved over the past decade and is now standardized with a high level of quality control, while providing a relatively inexpensive and reliable alternative to studying various aspects of gene expression.",

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author = "Trachtenberg, {Alexander J.} and Robert, {Jae Hyung} and Abdalla, {Azza E.} and Andrew Fraser and He, {Steven Y.} and Lacy, {Jessica N.} and Chiara Rivas-Morello and Allison Truong and Gary Hardiman and Lucila Ohno-Machado and Fang Liu and Eivind Hovig and Kuo, {Winston Patrick}",

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Trachtenberg, AJ, Robert, JH, Abdalla, AE, Fraser, A, He, SY, Lacy, JN, Rivas-Morello, C, Truong, A, Hardiman, G, Ohno-Machado, L, Liu, F, Hovig, E & Kuo, WP 2012, A primer on the current state of microarray technologies. in J Wang, T Tian & AC Tan (eds), Next Generation Microarray Bioinformatics: Methods and Protocols. Methods in Molecular Biology, vol. 802, pp. 3-17. https://doi.org/10.1007/978-1-61779-400-1_1

A primer on the current state of microarray technologies. / Trachtenberg, Alexander J.; Robert, Jae Hyung; Abdalla, Azza E. et al.
Next Generation Microarray Bioinformatics: Methods and Protocols. ed. / Junbai Wang; Tianhai Tian; Aik Choon Tan. 2012. p. 3-17 (Methods in Molecular Biology; Vol. 802).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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A primer on the current state of microarray technologies

Abstract

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Keywords

ASJC Scopus subject areas

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