A proposed model membrane and test method for microneedle insertion studies

Eneko Larrañeta, Jessica Moore, Eva M. Vicente-Perez, Patricia Gonzalez-Vazquez, Rebecca Lutton, A. David Woolfson, Ryan F. Donnelly*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

156 Citations (Scopus)

Abstract

A commercial polymeric film (Parafilm M (R), a blend of a hydrocarbon wax and a polyolefin) was evaluated as a model membrane for microneedle (MN) insertion studies. Polymeric MN arrays were inserted into Parafilm M (R) (PF) and also into excised neonatal porcine skin. Parafilm M (R) was folded before the insertions to closely approximate thickness of the excised skin. Insertion depths were evaluated using optical coherence tomography (OCT) using either a force applied by a Texture Analyser or by a group of human volunteers. The obtained insertion depths were, in general, slightly lower, especially for higher forces, for PF than for skin. However, this difference was not a large, being less than the 10% of the needle length. Therefore, all these data indicate that this model membrane could be a good alternative to biological tissue for MN insertion studies. As an alternative method to OCT, light microscopy was used to evaluate the insertion depths of MN in the model membrane. This provided a rapid, simple method to compare different MN formulations. The use of Parafilm M (R), in conjunction with a standardised force/time profile applied by a Texture Analyser, could provide the basis for a rapid MN quality control test suitable for in-process use. It could also be used as a comparative test of insertion efficiency between candidate MN formulations. 

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume472
Issue number1-2
Early online date28 May 2014
DOIs
Publication statusPublished - 10 Sep 2014

Keywords

  • Microneedles
  • Insertion tests
  • Polymeric films
  • Optical coherence tomography
  • TRANSDERMAL DRUG-DELIVERY
  • OPTICAL COHERENCE TOMOGRAPHY
  • CO-MALEIC ACID)
  • HUMAN SKIN
  • IN-VIVO
  • ARRAYS
  • PERMEATION
  • PARAMETERS
  • HYDROGELS

Fingerprint

Dive into the research topics of 'A proposed model membrane and test method for microneedle insertion studies'. Together they form a unique fingerprint.

Cite this