A psychosocial intervention for individuals with advanced chronic kidney disease: a feasibility randomised controlled trial

Zoe M. Jenkins; Eric J. Tan; Emmet O'Flaherty; Simon Knowles; David, R. Thompson; Chantal F. Ski; Susan L. Rossell; Carolee Coco; Francesco L. Ierino; Hilton Gock; David J. Castle

doi:10.1111/nep.13850

A psychosocial intervention for individuals with advanced chronic kidney disease: a feasibility randomised controlled trial

Zoe M. Jenkins, Eric J. Tan, Emmet O'Flaherty, Simon Knowles, David, R. Thompson , Chantal F. Ski, Susan L. Rossell, Carolee Coco, Francesco L. Ierino, Hilton Gock, David J. Castle

School of Nursing and Midwifery

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12 Citations (Scopus)

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Abstract

Aim

The current study evaluated the feasibility and preliminary efficacy of a psychosocial intervention, the Kidney Optimal Health Program, in reducing symptoms of depression and anxiety in individuals with advanced chronic kidney disease.

Methods

Patients with stage 4 or 5 chronic kidney disease were randomized to either a nine‐session psychosocial intervention programme or usual care. Feasibility was assessed through recruitment and retention rates and programme acceptability. Participants completed assessments of depression, anxiety and psychosocial health at baseline and at 3‐, 6‐ and 12‐month follow‐up. A repeated‐measures analysis of variance was used to compare groups on outcomes over time.

Results

One hundred and twenty‐eight patients were screened for eligibility; 84 consented to participant and were randomized to receive the intervention (N = 42) or usual care (N = 42). 27 (32.1%) participants withdrew prior to baseline assessment. Of those who completed the baseline assessment (N = 57), trial retention was high (75.4% at 3‐month, 80.7% at 6‐month and 70.2% at 12‐month follow‐up). Participants reported high levels of programme acceptability. The patients who completed the intervention (N = 17) demonstrated significantly decreased depression at 12‐month follow‐up compared to the usual care group (N = 13).

Conclusion

The results support the feasibility of the Kidney Optimal Health Program intervention in recruitment, retention and programme acceptability with an improved screening protocol. Preliminary support is provided for improvement in depressive symptoms in patients with advanced chronic kidney disease. Further investigation through a fully powered randomized controlled trial is warranted.

Original language	English
Pages (from-to)	442-453
Number of pages	12
Journal	Nephrology
Volume	26
Issue number	5
Early online date	23 Jan 2021
DOIs	https://doi.org/10.1111/nep.13850
Publication status	Published - May 2021

Keywords

Nephrology
General Medicine

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A psychosocial intervention for individuals with advanced chronic kidney disease: a feasibility randomised controlled trial
Copyright 2021 Wiley. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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Cite this

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title = "A psychosocial intervention for individuals with advanced chronic kidney disease: a feasibility randomised controlled trial",

abstract = "AimThe current study evaluated the feasibility and preliminary efficacy of a psychosocial intervention, the Kidney Optimal Health Program, in reducing symptoms of depression and anxiety in individuals with advanced chronic kidney disease.MethodsPatients with stage 4 or 5 chronic kidney disease were randomized to either a nine‐session psychosocial intervention programme or usual care. Feasibility was assessed through recruitment and retention rates and programme acceptability. Participants completed assessments of depression, anxiety and psychosocial health at baseline and at 3‐, 6‐ and 12‐month follow‐up. A repeated‐measures analysis of variance was used to compare groups on outcomes over time.ResultsOne hundred and twenty‐eight patients were screened for eligibility; 84 consented to participant and were randomized to receive the intervention (N = 42) or usual care (N = 42). 27 (32.1%) participants withdrew prior to baseline assessment. Of those who completed the baseline assessment (N = 57), trial retention was high (75.4% at 3‐month, 80.7% at 6‐month and 70.2% at 12‐month follow‐up). Participants reported high levels of programme acceptability. The patients who completed the intervention (N = 17) demonstrated significantly decreased depression at 12‐month follow‐up compared to the usual care group (N = 13).ConclusionThe results support the feasibility of the Kidney Optimal Health Program intervention in recruitment, retention and programme acceptability with an improved screening protocol. Preliminary support is provided for improvement in depressive symptoms in patients with advanced chronic kidney disease. Further investigation through a fully powered randomized controlled trial is warranted.",

keywords = "Nephrology, General Medicine",

author = "Jenkins, {Zoe M.} and Tan, {Eric J.} and Emmet O'Flaherty and Simon Knowles and Thompson, {David, R.} and Ski, {Chantal F.} and Rossell, {Susan L.} and Carolee Coco and Ierino, {Francesco L.} and Hilton Gock and Castle, {David J.}",

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doi = "10.1111/nep.13850",

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AU - Jenkins, Zoe M.

AU - Tan, Eric J.

AU - O'Flaherty, Emmet

AU - Knowles, Simon

AU - Thompson , David, R.

AU - Ski, Chantal F.

AU - Rossell, Susan L.

AU - Coco, Carolee

AU - Ierino, Francesco L.

AU - Gock, Hilton

AU - Castle, David J.

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N2 - AimThe current study evaluated the feasibility and preliminary efficacy of a psychosocial intervention, the Kidney Optimal Health Program, in reducing symptoms of depression and anxiety in individuals with advanced chronic kidney disease.MethodsPatients with stage 4 or 5 chronic kidney disease were randomized to either a nine‐session psychosocial intervention programme or usual care. Feasibility was assessed through recruitment and retention rates and programme acceptability. Participants completed assessments of depression, anxiety and psychosocial health at baseline and at 3‐, 6‐ and 12‐month follow‐up. A repeated‐measures analysis of variance was used to compare groups on outcomes over time.ResultsOne hundred and twenty‐eight patients were screened for eligibility; 84 consented to participant and were randomized to receive the intervention (N = 42) or usual care (N = 42). 27 (32.1%) participants withdrew prior to baseline assessment. Of those who completed the baseline assessment (N = 57), trial retention was high (75.4% at 3‐month, 80.7% at 6‐month and 70.2% at 12‐month follow‐up). Participants reported high levels of programme acceptability. The patients who completed the intervention (N = 17) demonstrated significantly decreased depression at 12‐month follow‐up compared to the usual care group (N = 13).ConclusionThe results support the feasibility of the Kidney Optimal Health Program intervention in recruitment, retention and programme acceptability with an improved screening protocol. Preliminary support is provided for improvement in depressive symptoms in patients with advanced chronic kidney disease. Further investigation through a fully powered randomized controlled trial is warranted.

AB - AimThe current study evaluated the feasibility and preliminary efficacy of a psychosocial intervention, the Kidney Optimal Health Program, in reducing symptoms of depression and anxiety in individuals with advanced chronic kidney disease.MethodsPatients with stage 4 or 5 chronic kidney disease were randomized to either a nine‐session psychosocial intervention programme or usual care. Feasibility was assessed through recruitment and retention rates and programme acceptability. Participants completed assessments of depression, anxiety and psychosocial health at baseline and at 3‐, 6‐ and 12‐month follow‐up. A repeated‐measures analysis of variance was used to compare groups on outcomes over time.ResultsOne hundred and twenty‐eight patients were screened for eligibility; 84 consented to participant and were randomized to receive the intervention (N = 42) or usual care (N = 42). 27 (32.1%) participants withdrew prior to baseline assessment. Of those who completed the baseline assessment (N = 57), trial retention was high (75.4% at 3‐month, 80.7% at 6‐month and 70.2% at 12‐month follow‐up). Participants reported high levels of programme acceptability. The patients who completed the intervention (N = 17) demonstrated significantly decreased depression at 12‐month follow‐up compared to the usual care group (N = 13).ConclusionThe results support the feasibility of the Kidney Optimal Health Program intervention in recruitment, retention and programme acceptability with an improved screening protocol. Preliminary support is provided for improvement in depressive symptoms in patients with advanced chronic kidney disease. Further investigation through a fully powered randomized controlled trial is warranted.

KW - Nephrology

KW - General Medicine

U2 - 10.1111/nep.13850

DO - 10.1111/nep.13850

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SN - 1440-1797

VL - 26

SP - 442

EP - 453

JO - Nephrology

JF - Nephrology

IS - 5

ER -

A psychosocial intervention for individuals with advanced chronic kidney disease: a feasibility randomised controlled trial

Abstract

Keywords

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