A randomised controlled trial of Acceptance and Commitment Therapy for improving quality of life in people with muscle diseases

Michael R Rose, Christopher Graham, Nicola O'Connell, Chiara Vari, Victoria Edwards, emma taylor, Lance McCracken, alexander radunovic, wojtek Rakowicz, Sam Norton, Trudie Chalder

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Abstract

Abstract. Chronic muscle diseases (MD) are progressive and cause wasting and weakness in muscles and are associated with reduced quality of life (QoL). The ACTMuS trial examined whether Acceptance and Commitment Therapy (ACT) as an adjunct to usual care improved QoL for such patients as compared to usual care alone. This two-arm, randomised, multicentre, parallel design recruited 155 patients with MD (Hospital and Depression Scale ⩾ 8 for depression or ⩾ 8 for anxiety and Montreal Cognitive Assessment ⩾ 21/30). Participants were randomised, using random block sizes, to one of two groups: standard medical care (SMC) (n = 78) or to ACT in addition to SMC (n = 77), and were followed up to 9 weeks. The primary outcome was QoL, assessed by the Individualised Neuromuscular Quality of Life Questionnaire (INQoL), the average of five subscales, at 9-weeks. Trial registration was NCT02810028. 138 people (89.0%) were followed up at 9-weeks. At all three time points, the adjusted group difference favoured the intervention group and was significant with moderate to large effect sizes. Secondary outcomes (mood, functional impairment, aspects of psychological flexibility) also showed significant differences between groups at week 9. ACT in addition to usual care was effective in improving QoL and other psychological and social outcomes in patients with MD. A 6 month follow up will determine the extent to which gains are maintained.
Original languageEnglish
Pages (from-to)1-14
JournalPsychological Medicine
Early online date23 Feb 2022
DOIs
Publication statusEarly online date - 23 Feb 2022

Keywords

  • Muscle diseases
  • acceptance and commitment therapy
  • quality of life
  • randomised controlled trial

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