A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

Doriad Alrifai, Sanjay Popat, Merina Ahmed, David Gonzalez, Andrew G. Nicholson, John du Parcq, Tim Benepal

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.
Original languageEnglish
Pages (from-to)339-340
Number of pages2
JournalLung Cancer
Volume80
Issue number3
Early online date14 Mar 2013
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Keywords

  • Lung cancer
  • Squamous cell carcinoma
  • ALK
  • EML4-ALK
  • BRAF
  • Coexistence
  • Coexisting
  • Activating mutations
  • Non-small cell lung cancer

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