The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.
- Lung cancer
- Squamous cell carcinoma
- Activating mutations
- Non-small cell lung cancer
Alrifai, D., Popat, S., Ahmed, M., Gonzalez, D., Nicholson, A. G., du Parcq, J., & Benepal, T. (2013). A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations. Lung Cancer, 80(3), 339-340. https://doi.org/10.1016/j.lungcan.2013.02.002