A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

Doriad Alrifai; Sanjay Popat; Merina Ahmed; David Gonzalez; Andrew G. Nicholson; John du Parcq; Tim Benepal

doi:10.1016/j.lungcan.2013.02.002

A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

Doriad Alrifai
, Sanjay Popat
, Merina Ahmed
, David Gonzalez
, Andrew G. Nicholson
, John du Parcq
, Tim Benepal

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.

Original language	English
Pages (from-to)	339-340
Number of pages	2
Journal	Lung Cancer
Volume	80
Issue number	3
Early online date	14 Mar 2013
DOIs	https://doi.org/10.1016/j.lungcan.2013.02.002
Publication status	Published - Jun 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lung cancer
Squamous cell carcinoma
ALK
EML4-ALK
BRAF
Coexistence
Coexisting
Activating mutations
Non-small cell lung cancer

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10.1016/j.lungcan.2013.02.002Licence: Unspecified

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Cite this

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title = "A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations",

abstract = "The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.",

keywords = "Lung cancer, Squamous cell carcinoma, ALK, EML4-ALK, BRAF, Coexistence, Coexisting, Activating mutations, Non-small cell lung cancer",

author = "Doriad Alrifai and Sanjay Popat and Merina Ahmed and David Gonzalez and Nicholson, \{Andrew G.\} and \{du Parcq\}, John and Tim Benepal",

year = "2013",

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doi = "10.1016/j.lungcan.2013.02.002",

language = "English",

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T1 - A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

AU - Alrifai, Doriad

AU - Popat, Sanjay

AU - Ahmed, Merina

AU - Gonzalez, David

AU - Nicholson, Andrew G.

AU - du Parcq, John

AU - Benepal, Tim

PY - 2013/6

Y1 - 2013/6

N2 - The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.

AB - The management of non-small cell lung cancer has significantly changed over the past few years through greater understanding of tumour biology. The identification of activating mutations has led to the development of targeted agents. Coexisting mutations in non-small cell lung cancer is uncommon, particularly in squamous cell carcinoma. Our case represents a late gentleman with squamous cell carcinoma of the lung with both a BRAF mutation and ALK rearrangement prior to treatment.

KW - Lung cancer

KW - Squamous cell carcinoma

KW - ALK

KW - EML4-ALK

KW - BRAF

KW - Coexistence

KW - Coexisting

KW - Activating mutations

KW - Non-small cell lung cancer

U2 - 10.1016/j.lungcan.2013.02.002

DO - 10.1016/j.lungcan.2013.02.002

M3 - Article

SN - 0169-5002

VL - 80

SP - 339

EP - 340

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

A rare case of squamous cell carcinoma of the lung harbouring ALK and BRAF activating mutations

Abstract

UN SDGs

Keywords

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