A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy

R.J.L. Martin, Amy Jayne McKnight, Christopher Patterson, D.M. Sadlier, Alexander Maxwell

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Background. Vitamin D and its analogues are reported to have renoprotective effects in chronic kidney disease including diabetic nephropathy (DN). Vitamin D3 is converted to 1,25(OH) D3 by CYP2R1 and CYP27B1. The biological action of 1,25(OH) D3 is mediated via its receptor. VDR, CYP27B1 or CYP2R1 gene variants could modify the biological activity of vitamin D3. We have conducted the first case- control association study to determine the relationship between polymorphisms in VDR, CYP27B1 and CYP2R1 genes, and the risk of DN in individuals with type 1 diabetes.
Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalNephrology Dialysis Transplantation
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy'. Together they form a unique fingerprint.

Cite this