A Role for Behavior in the Relationships Between Depression and Hostility and Cardiovascular Disease Incidence, Mortality, and All-Cause Mortality: the Prime Study

K M Appleton, J V Woodside, D Arveiler, B Haas, P Amouyel, M Montaye, J Ferrieres, J B Ruidavets, J W G Yarnell, F Kee, A Evans, A Bingham, P Ducimetiere, C C Patterson, PRIME study group

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Abstract

BACKGROUND: Behavioral factors are important in disease incidence and mortality and may explain associations between mortality and various psychological traits.

PURPOSE: These analyses investigated the impact of behavioral factors on the associations between depression, hostility and cardiovascular disease(CVD) incidence, CVD mortality, and all-cause mortality.

METHODS: Data from the PRIME Study (N = 6953 men) were analyzed using Cox proportional hazards models, following adjustment for demographic and biological CVD risk factors, and other psychological traits, including social support.

RESULTS: Following initial adjustment, both depression and hostility were significantly associated with both mortality outcomes (smallest SHR = 1.24, p < 0.001). Following adjustment for behavioral factors, all relationships were attenuated both when accounting for and not accounting for other psychological variables. Associations with all-cause mortality remained significant (smallest SHR = 1.14, p = 0.04). Of the behaviors included, the most significant contribution to outcomes was found for smoking, but a role was also found for fruit and vegetable intakes and high alcohol consumption.

CONCLUSIONS: These findings demonstrate well-known associations between depression, hostility, and mortality and suggest the potential importance of behaviors in explaining these relationships.

Original languageEnglish
Pages (from-to)582-591
Number of pages10
JournalAnnals of Behavioral Medicine
Volume50
Issue number4
Early online date15 Mar 2016
DOIs
Publication statusPublished - Aug 2016

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  • Cite this

    Appleton, K. M., Woodside, J. V., Arveiler, D., Haas, B., Amouyel, P., Montaye, M., Ferrieres, J., Ruidavets, J. B., Yarnell, J. W. G., Kee, F., Evans, A., Bingham, A., Ducimetiere, P., Patterson, C. C., & PRIME study group (2016). A Role for Behavior in the Relationships Between Depression and Hostility and Cardiovascular Disease Incidence, Mortality, and All-Cause Mortality: the Prime Study. Annals of Behavioral Medicine , 50(4), 582-591. https://doi.org/10.1007/s12160-016-9784-x