A Role for Behavior in the Relationships Between Depression and Hostility and Cardiovascular Disease Incidence, Mortality, and All-Cause Mortality: the Prime Study

K M Appleton, J V Woodside, D Arveiler, B Haas, P Amouyel, M Montaye, J Ferrieres, J B Ruidavets, J W G Yarnell, F Kee, A Evans, A Bingham, P Ducimetiere, C C Patterson, PRIME study group

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
220 Downloads (Pure)

Abstract

BACKGROUND: Behavioral factors are important in disease incidence and mortality and may explain associations between mortality and various psychological traits.

PURPOSE: These analyses investigated the impact of behavioral factors on the associations between depression, hostility and cardiovascular disease(CVD) incidence, CVD mortality, and all-cause mortality.

METHODS: Data from the PRIME Study (N = 6953 men) were analyzed using Cox proportional hazards models, following adjustment for demographic and biological CVD risk factors, and other psychological traits, including social support.

RESULTS: Following initial adjustment, both depression and hostility were significantly associated with both mortality outcomes (smallest SHR = 1.24, p < 0.001). Following adjustment for behavioral factors, all relationships were attenuated both when accounting for and not accounting for other psychological variables. Associations with all-cause mortality remained significant (smallest SHR = 1.14, p = 0.04). Of the behaviors included, the most significant contribution to outcomes was found for smoking, but a role was also found for fruit and vegetable intakes and high alcohol consumption.

CONCLUSIONS: These findings demonstrate well-known associations between depression, hostility, and mortality and suggest the potential importance of behaviors in explaining these relationships.

Original languageEnglish
Pages (from-to)582-591
Number of pages10
JournalAnnals of Behavioral Medicine
Volume50
Issue number4
Early online date15 Mar 2016
DOIs
Publication statusPublished - Aug 2016

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