A schizophrenia locus may be located in region 10p15-p11

R E Straub, C J MacLean, R B Martin, Y Ma, M V Myakishev, C Harris-Kerr, B T Webb, F A O'Neill, D Walsh, K S Kendler

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Abstract

In our genomic scan of 265 Irish families with schizophrenia, we have thus far generated modest evidence for the presence of vulnerability genes in three chromosomal regions, i.e., 5q21-q31, 6p24-p22, and 8p22-p21. Outside of those regions, of all markers tested to date, D10S674 produced one of the highest pairwise heterogeneity lod (H-LOD) scores, 3.2 (P = 0.0004), when initially tested on a subset of 88 families. We then tested a total of 12 markers across a region of 32 centimorgans in region 10p15-p11 of all 265 families. The strongest evidence for linkage occurred assuming an intermediate phenotypic definition, and a recessive genetic model. The largest pairwise H-LOD score was found with marker D10S2443 (maximum 1.95, P = 0.005). Using multipoint H-LODs, we found a broad peak (maximum 1.91, P = 0.006) extending over the 11 centimorgans from marker D10S674 to marker D10S1426. Multipoint nonparametric linkage analysis produced a much broader peak, but with the maximum in the same location near D10S2443 (maximum z = 1.88, P = 0.03). Based on estimates from the multipoint analysis, this putative vulnerability locus appears to be segregating in 5-15% of the families studied, but this estimate should be viewed with caution. When evaluated in the context of our genome scan results, the evidence suggests the possibility of a fourth vulnerability locus for schizophrenia in these Irish families, in region 10p15-p11.
Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume81
Issue number4
Publication statusPublished - 10 Jul 1998

Keywords

  • Chromosome Mapping
  • Chromosomes, Human, Pair 10
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genotype
  • Humans
  • Ireland
  • Lod Score
  • Male
  • Pedigree
  • Schizophrenia

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    Straub, R. E., MacLean, C. J., Martin, R. B., Ma, Y., Myakishev, M. V., Harris-Kerr, C., Webb, B. T., O'Neill, F. A., Walsh, D., & Kendler, K. S. (1998). A schizophrenia locus may be located in region 10p15-p11. American Journal of Medical Genetics, 81(4), 296-301.