A Synthesis of (S)-(-)-Umbelactone and Related α,β-Butenolides

William Goldring; John Mann; Paul Brockbank

doi:10.1055/s-0029-1219181

A Synthesis of (S)-(-)-Umbelactone and Related α,β-Butenolides

William Goldring
, John Mann
, Paul Brockbank

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The development of an asymmetric route for the synthesis of alpha,beta-butenolide building blocks, starting from commercially available D-mannitol, is described. The devised route was applied to a synthesis of the (S)-(–)-enantiomer of the antiviral natural product umbelactone, together with the construction of other synthetically useful lactone structures.

Original language	English
Article number	D29309ST
Pages (from-to)	547-550
Number of pages	4
Journal	Synlett
Volume	2010
Issue number	4
DOIs	https://doi.org/10.1055/s-0029-1219181
Publication status	Published - Mar 2010

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0029-1219181

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title = "A Synthesis of (S)-(-)-Umbelactone and Related α,β-Butenolides",

abstract = "The development of an asymmetric route for the synthesis of alpha,beta-butenolide building blocks, starting from commercially available D-mannitol, is described. The devised route was applied to a synthesis of the (S)-(–)-enantiomer of the antiviral natural product umbelactone, together with the construction of other synthetically useful lactone structures.",

author = "William Goldring and John Mann and Paul Brockbank",

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T1 - A Synthesis of (S)-(-)-Umbelactone and Related α,β-Butenolides

AU - Goldring, William

AU - Mann, John

AU - Brockbank, Paul

PY - 2010/3

Y1 - 2010/3

N2 - The development of an asymmetric route for the synthesis of alpha,beta-butenolide building blocks, starting from commercially available D-mannitol, is described. The devised route was applied to a synthesis of the (S)-(–)-enantiomer of the antiviral natural product umbelactone, together with the construction of other synthetically useful lactone structures.

AB - The development of an asymmetric route for the synthesis of alpha,beta-butenolide building blocks, starting from commercially available D-mannitol, is described. The devised route was applied to a synthesis of the (S)-(–)-enantiomer of the antiviral natural product umbelactone, together with the construction of other synthetically useful lactone structures.

UR - https://www.scopus.com/pages/publications/77955368300

U2 - 10.1055/s-0029-1219181

DO - 10.1055/s-0029-1219181

M3 - Article

VL - 2010

SP - 547

EP - 550

JO - Synlett

JF - Synlett

IS - 4

M1 - D29309ST

ER -

A Synthesis of (S)-(-)-Umbelactone and Related α,β-Butenolides

Abstract

ASJC Scopus subject areas

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