A two-stage meta-analysis identifies several new loci for Parkinson's disease

Karen Morrison

doi:10.1371/journal.pgen.1002142

A two-stage meta-analysis identifies several new loci for Parkinson's disease

Karen Morrison

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article

189 Citations (Scopus)

Abstract

A previous genome-wide association (GWA) meta-analysis of 12,386 PD cases and 21,026 controls conducted by the International Parkinson's Disease Genomics Consortium (IPDGC) discovered or confirmed 11 Parkinson's disease (PD) loci. This first analysis of the two-stage IPDGC study focused on the set of loci that passed genome-wide significance in the first stage GWA scan. However, the second stage genotyping array, the ImmunoChip, included a larger set of 1,920 SNPs selected on the basis of the GWA analysis. Here, we analyzed this set of 1,920 SNPs, and we identified five additional PD risk loci (combined p

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	PLoS Genetics
Volume	7
Issue number	6
DOIs	https://doi.org/10.1371/journal.pgen.1002142
Publication status	Published - 30 Jun 2011

Bibliographical note

International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

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Morrison, K. (2011). A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genetics, 7(6), 1-9. https://doi.org/10.1371/journal.pgen.1002142

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