AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models

Sophia Millington-Ward; Naomi Chadderton; Laura K Finnegan; Iris J M Post; Matthew Carrigan; Tom Gardiner; Elisa Peixoto; Daniel Maloney; Marian M Humphries; Alan Stitt; Thierry Léveillard; Pete Humphries; Paul F Kenna; Arpad Palfi; G Jane Farrar

doi:10.1002/ctm2.952

AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models

Sophia Millington-Ward, Naomi Chadderton, Laura K Finnegan, Iris J M Post, Matthew Carrigan, Tom Gardiner, Elisa Peixoto, Daniel Maloney, Marian M Humphries, Alan Stitt, Thierry Léveillard, Pete Humphries, Paul F Kenna, Arpad Palfi, G Jane Farrar

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Letter › peer-review

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Original language	English
Article number	e952
Journal	Clinical and Translational Medicine
Volume	12
Issue number	8
DOIs	https://doi.org/10.1002/ctm2.952
Publication status	Published - 21 Aug 2022

Keywords

Humans
Mitochondria - genetics
Genetic Therapy
Dependovirus - genetics
Macular Degeneration - genetics - therapy

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10.1002/ctm2.952Licence: CC BY

AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited
Final published version, 2.43 MBLicence: CC BY

Cite this

Millington-Ward, S., Chadderton, N., Finnegan, L. K., Post, I. J. M., Carrigan, M., Gardiner, T., Peixoto, E., Maloney, D., Humphries, M. M., Stitt, A., Léveillard, T., Humphries, P., Kenna, P. F., Palfi, A., & Farrar, G. J. (2022). AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models. Clinical and Translational Medicine, 12(8), Article e952. https://doi.org/10.1002/ctm2.952

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title = "AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models",

keywords = "Humans, Mitochondria - genetics, Genetic Therapy, Dependovirus - genetics, Macular Degeneration - genetics - therapy",

author = "Sophia Millington-Ward and Naomi Chadderton and Finnegan, {Laura K} and Post, {Iris J M} and Matthew Carrigan and Tom Gardiner and Elisa Peixoto and Daniel Maloney and Humphries, {Marian M} and Alan Stitt and Thierry L{\'e}veillard and Pete Humphries and Kenna, {Paul F} and Arpad Palfi and Farrar, {G Jane}",

year = "2022",

month = aug,

day = "21",

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Millington-Ward, S, Chadderton, N, Finnegan, LK, Post, IJM, Carrigan, M, Gardiner, T, Peixoto, E, Maloney, D, Humphries, MM, Stitt, A, Léveillard, T, Humphries, P, Kenna, PF, Palfi, A & Farrar, GJ 2022, 'AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models', Clinical and Translational Medicine, vol. 12, no. 8, e952. https://doi.org/10.1002/ctm2.952

TY - JOUR

T1 - AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models

AU - Millington-Ward, Sophia

AU - Chadderton, Naomi

AU - Finnegan, Laura K

AU - Post, Iris J M

AU - Carrigan, Matthew

AU - Gardiner, Tom

AU - Peixoto, Elisa

AU - Maloney, Daniel

AU - Humphries, Marian M

AU - Stitt, Alan

AU - Léveillard, Thierry

AU - Humphries, Pete

AU - Kenna, Paul F

AU - Palfi, Arpad

AU - Farrar, G Jane

PY - 2022/8/21

Y1 - 2022/8/21

KW - Humans

KW - Mitochondria - genetics

KW - Genetic Therapy

KW - Dependovirus - genetics

KW - Macular Degeneration - genetics - therapy

U2 - 10.1002/ctm2.952

DO - 10.1002/ctm2.952

M3 - Letter

C2 - 35988157

SN - 2001-1326

VL - 12

JO - Clinical and Translational Medicine

JF - Clinical and Translational Medicine

IS - 8

M1 - e952

ER -