ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Katrin E Rhodes; Wu Zhang; Dongyun Yang; Oliver A Press; Michael Gordon; Daniel Vallböhmer; Anne M Schultheis; Georg Lurje; Robert D Ladner; William Fazzone; Syma Iqbal; Heinz-Josef Lenz

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Katrin E Rhodes, Wu Zhang, Dongyun Yang, Oliver A Press, Michael Gordon, Daniel Vallböhmer, Anne M Schultheis, Georg Lurje, Robert D Ladner, William Fazzone, Syma Iqbal, Heinz-Josef Lenz

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

Original language	English
Pages (from-to)	23-30
Number of pages	8
Journal	Drug metabolism letters
Volume	1
Issue number	1
Publication status	Published - Jan 2007

Keywords

ATP Binding Cassette Transporter, Sub-Family B
ATP-Binding Cassette, Sub-Family B, Member 1
Adult
Aged
Alleles
Antineoplastic Agents, Phytogenic
Camptothecin
Colorectal Neoplasms
Female
Glucuronosyltransferase
Humans
Male
Middle Aged
Neoplasm Metastasis
Organic Anion Transporters
Polymorphism, Genetic
Prospective Studies
Retrospective Studies
Solute Carrier Organic Anion Transporter Family Member 1b1
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan",

abstract = "We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.",

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author = "Rhodes, {Katrin E} and Wu Zhang and Dongyun Yang and Press, {Oliver A} and Michael Gordon and Daniel Vallb{\"o}hmer and Schultheis, {Anne M} and Georg Lurje and Ladner, {Robert D} and William Fazzone and Syma Iqbal and Heinz-Josef Lenz",

year = "2007",

month = jan,

language = "English",

volume = "1",

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journal = "Drug metabolism letters",

issn = "1872-3128",

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T1 - ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

AU - Rhodes, Katrin E

AU - Zhang, Wu

AU - Yang, Dongyun

AU - Press, Oliver A

AU - Gordon, Michael

AU - Vallböhmer, Daniel

AU - Schultheis, Anne M

AU - Lurje, Georg

AU - Ladner, Robert D

AU - Fazzone, William

AU - Iqbal, Syma

AU - Lenz, Heinz-Josef

PY - 2007/1

Y1 - 2007/1

N2 - We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

AB - We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

KW - ATP Binding Cassette Transporter, Sub-Family B

KW - ATP-Binding Cassette, Sub-Family B, Member 1

KW - Adult

KW - Aged

KW - Alleles

KW - Antineoplastic Agents, Phytogenic

KW - Camptothecin

KW - Colorectal Neoplasms

KW - Female

KW - Glucuronosyltransferase

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Metastasis

KW - Organic Anion Transporters

KW - Polymorphism, Genetic

KW - Prospective Studies

KW - Retrospective Studies

KW - Solute Carrier Organic Anion Transporter Family Member 1b1

KW - Clinical Trial

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

M3 - Article

C2 - 19356014

SN - 1872-3128

VL - 1

SP - 23

EP - 30

JO - Drug metabolism letters

JF - Drug metabolism letters

IS - 1

ER -

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Abstract

Keywords

UN SDGs

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