ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Katrin E Rhodes, Wu Zhang, Dongyun Yang, Oliver A Press, Michael Gordon, Daniel Vallböhmer, Anne M Schultheis, Georg Lurje, Robert D Ladner, William Fazzone, Syma Iqbal, Heinz-Josef Lenz

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We tested specific gene polymorphisms known to be involved in the irinotecan (CPT-11) metabolic pathway. The combination of at least one SLCO1B1 521 T allele, one ABCB1 1236 C allele and one UGT1A1*28 variant 7 repeat demonstrated a statistically significant association with Grade 3/4 toxicities in metastatic colorectal cancer patients.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalDrug metabolism letters
Volume1
Issue number1
Publication statusPublished - Jan 2007

Keywords

  • ATP Binding Cassette Transporter, Sub-Family B
  • ATP-Binding Cassette, Sub-Family B, Member 1
  • Adult
  • Aged
  • Alleles
  • Antineoplastic Agents, Phytogenic
  • Camptothecin
  • Colorectal Neoplasms
  • Female
  • Glucuronosyltransferase
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Organic Anion Transporters
  • Polymorphism, Genetic
  • Prospective Studies
  • Retrospective Studies
  • Solute Carrier Organic Anion Transporter Family Member 1b1
  • Clinical Trial
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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