Acellular fish skin grafts in the treatment of diabetic wounds: Advantages and clinical translation

Chenyu Zhao, Mengyi Feng, Martin Gluchman, Xianghe Ma, Jinhao Li, Hui Wang

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Diabetic wounds cannot undergo normal wound healing due to changes in the concentration of hyperglycemia in the body and soon evolve into chronic wounds causing amputation or even death of patients. Diabetic wounds directly affect the quality of patients and social medical management; thus researchers started to focus on skin transplantation technology. The acellular fish skin grafts (AFSGs) are derived from wild fish, which avoids the influence of human immune function and the spread of the virus through low-cost decellularization. AFSGs contain a large amount of collagen and omega-3 polyunsaturated fatty acids and they have an amazing effect on wound regeneration. However, after our search in major databases, we found that there were few research trials in this field, and only one was clinically approved. Therefore, we summarized the advantages of AFSGs and listed the problems faced in clinical use. The purpose of this paper is to enable researchers to better carry out original experiments at various stages.
Original languageEnglish
Article numbere13554
Number of pages12
JournalJournal of Diabetes
Issue number5
Early online date25 Apr 2024
Publication statusPublished - 01 May 2024


  • Wound healing
  • Diabetes
  • Diabetic Wounds
  • Acellular Fish Skin
  • Fish Skin Graft
  • Advanced Bandage
  • Animals
  • Fishes
  • Humans
  • Diabetic Foot
  • Skin Transplantation
  • Wound Healing


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