Acid-mediated topological control in a functionalized foldamer

Peter C. Knipe, Sam Thompson, Andrew D. Hamilton

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.

LanguageEnglish
Pages6521-6524
Number of pages4
JournalChemical Communications
Volume52
Issue number39
Early online date21 Mar 2016
DOIs
Publication statusPublished - 2016

Fingerprint

Pyridine
Topology
Molecules
Acids
pyridine
ethylene urea

Keywords

  • foldamer
  • switching
  • oligomer
  • acid
  • conformation
  • supramolecular
  • helix

Cite this

Knipe, Peter C. ; Thompson, Sam ; Hamilton, Andrew D. / Acid-mediated topological control in a functionalized foldamer. In: Chemical Communications. 2016 ; Vol. 52, No. 39. pp. 6521-6524.
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Knipe, PC, Thompson, S & Hamilton, AD 2016, 'Acid-mediated topological control in a functionalized foldamer', Chemical Communications, vol. 52, no. 39, pp. 6521-6524. https://doi.org/10.1039/c6cc01496h

Acid-mediated topological control in a functionalized foldamer. / Knipe, Peter C.; Thompson, Sam; Hamilton, Andrew D.

In: Chemical Communications, Vol. 52, No. 39, 2016, p. 6521-6524.

Research output: Contribution to journal › Article

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AU - Knipe, Peter C.

AU - Thompson, Sam

AU - Hamilton, Andrew D.

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AB - Induced conformational change provides a powerful mechanism to modulate the structure and function of molecules. Here we describe the synthesis of chiral, surface-functionalized oligomeric pyridine/imidazolidin-2-one foldamers, and interrogate their acid-mediated transition between linear and helical topologies.

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KW - switching

KW - oligomer

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KW - conformation

KW - supramolecular

KW - helix

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Knipe PC, Thompson S, Hamilton AD. Acid-mediated topological control in a functionalized foldamer. Chemical Communications. 2016;52(39):6521-6524. https://doi.org/10.1039/c6cc01496h

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