Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

Yunzhou Dong, Miao Zhang, Shuangxi Wang, Bin Liang, Zhengxing Zhao, Chao Liu, Mingyuan Wu, Hyoung Chul Choi, Timothy J Lyons, Ming-Hui Zou

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.
Original languageEnglish
Pages (from-to)1386-96
Number of pages11
JournalDiabetes
Volume59
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • AMP-Activated Protein Kinases
  • Animals
  • Aorta
  • Apolipoproteins E
  • Cattle
  • Crosses, Genetic
  • Endoplasmic Reticulum
  • Endothelium, Vascular
  • Enzyme Activation
  • Gene Expression Regulation
  • Humans
  • Lipoproteins, LDL
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Small Interfering
  • Umbilical Veins

Fingerprint

Dive into the research topics of 'Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo'. Together they form a unique fingerprint.

Cite this