Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

Yunzhou Dong; Miao Zhang; Shuangxi Wang; Bin Liang; Zhengxing Zhao; Chao Liu; Mingyuan Wu; Hyoung Chul Choi; Timothy J Lyons; Ming-Hui Zou

doi:10.2337/db09-1637

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

Yunzhou Dong
, Miao Zhang
, Shuangxi Wang
, Bin Liang
, Zhengxing Zhao
, Chao Liu
, Mingyuan Wu
, Hyoung Chul Choi
, Timothy J Lyons
, Ming-Hui Zou

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

172 Citations (Scopus)

Abstract

The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.

Original language	English
Pages (from-to)	1386-96
Number of pages	11
Journal	Diabetes
Volume	59
Issue number	6
DOIs	https://doi.org/10.2337/db09-1637
Publication status	Published - Jun 2010

Keywords

AMP-Activated Protein Kinases
Animals
Aorta
Apolipoproteins E
Cattle
Crosses, Genetic
Endoplasmic Reticulum
Endothelium, Vascular
Enzyme Activation
Gene Expression Regulation
Humans
Lipoproteins, LDL
Mice
Mice, Inbred C57BL
Mice, Knockout
RNA, Small Interfering
Umbilical Veins

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10.2337/db09-1637

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title = "Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo",

abstract = "The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.",

keywords = "AMP-Activated Protein Kinases, Animals, Aorta, Apolipoproteins E, Cattle, Crosses, Genetic, Endoplasmic Reticulum, Endothelium, Vascular, Enzyme Activation, Gene Expression Regulation, Humans, Lipoproteins, LDL, Mice, Mice, Inbred C57BL, Mice, Knockout, RNA, Small Interfering, Umbilical Veins",

author = "Yunzhou Dong and Miao Zhang and Shuangxi Wang and Bin Liang and Zhengxing Zhao and Chao Liu and Mingyuan Wu and Choi, \{Hyoung Chul\} and Lyons, \{Timothy J\} and Ming-Hui Zou",

year = "2010",

month = jun,

doi = "10.2337/db09-1637",

language = "English",

volume = "59",

pages = "1386--96",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association Inc.",

number = "6",

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TY - JOUR

T1 - Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

AU - Dong, Yunzhou

AU - Zhang, Miao

AU - Wang, Shuangxi

AU - Liang, Bin

AU - Zhao, Zhengxing

AU - Liu, Chao

AU - Wu, Mingyuan

AU - Choi, Hyoung Chul

AU - Lyons, Timothy J

AU - Zou, Ming-Hui

PY - 2010/6

Y1 - 2010/6

N2 - The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.

AB - The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER stress in vivo.

KW - AMP-Activated Protein Kinases

KW - Animals

KW - Aorta

KW - Apolipoproteins E

KW - Cattle

KW - Crosses, Genetic

KW - Endoplasmic Reticulum

KW - Endothelium, Vascular

KW - Enzyme Activation

KW - Gene Expression Regulation

KW - Humans

KW - Lipoproteins, LDL

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - RNA, Small Interfering

KW - Umbilical Veins

U2 - 10.2337/db09-1637

DO - 10.2337/db09-1637

M3 - Article

C2 - 20299472

SN - 0012-1797

VL - 59

SP - 1386

EP - 1396

JO - Diabetes

JF - Diabetes

IS - 6

ER -

Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo

Abstract

Keywords

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