Active immunisation of lambs with a monoclonal antibody against clenbuterol

Alistair Carson, Christopher Elliott, Dermot Mackie, Derek McCaughey

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Abstract

An experiment was undertaken with 50 Texel x Suffolk-Cheviot lambs (54+/-8.8 days of age) to investigate the effects of active immunisation with a murine monoclonal antibody against clenburerol on growth and carcass characteristics. Animals on treatments 1 and 2 each received 0.1 mg of clenbuterol antibody while animals on treatments 3 and 4 received 0.1 mg of antibody encapsulated within a synthetic polymer. Diethylaminoethyl (DEAE)-dextran was used as the adjuvant in treatments 1 and 3 and saponin in treatments 2 and 4. Control animals were immunised with saponin only. Four immunisations were given at 4-week intervals. Animals were slaughtered 3 weeks after the final immunisation. Each vaccine evoked a similar level of antibody response while the control group showed no titres. Lamb growth rate did not vary significantly between the vaccinated and control groups. Dressing proportion was higher (P
Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalLivestock Production Science
Volume68
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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