Adenosine, inflammation and asthma - a review

M. Livingston, Liam Heaney, Madeleine Ennis

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Adenosine is a ubiquitous molecule present in every cell of the human body. It has a wide range of physiological functions mediated predominantly through specific cell surface adenosine receptors. Adenosine has both pro- and anti-inflammatory effects and acts on inflammatory and resident immune cells and antioxidant enzymes. The elevation of adenosine in the bronchoalveolar lavage (BAL) fluid of asthmatics combined with its bronchoconstrictor effect on the airways in asthmatics has led to increased research into the contribution of adenosine in the pathophysiology of inflammation and asthma. This review looks at the airway response to adenosine and at the interaction of adenosine with mast cells and basophils.
Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalInflammation research : official journal of the European Histamine Research Society ... [et al.]
Volume53
Issue number5
DOIs
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Cell Biology
  • Immunology
  • Pharmacology (medical)
  • Toxicology

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