Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes

Y Yu, S R Thorpe, A J Jenkins, J N Shaw, M A Sochaski, D McGee, C E Aston, T J Orchard, N Silvers, Y G Peng, J A McKnight, J W Baynes, T J Lyons, DCCT/EDIC Research Group

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

We determined whether oxidative damage in collagen is increased in (1) patients with diabetes; (2) patients with diabetic complications; and (3) subjects from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study, with comparison of subjects from the former standard vs intensive treatment groups 4 years after DCCT completion.
Original languageEnglish
Pages (from-to)2488-98
Number of pages11
JournalDiabetologia
Volume49
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Adult
  • Aged
  • Biopsy
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Collagen
  • Diabetes Mellitus, Type 1
  • Female
  • Glycosylation End Products, Advanced
  • Hemoglobin A, Glycosylated
  • Humans
  • Male
  • Methionine
  • Middle Aged
  • Reference Values
  • Skin
  • Triglycerides

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