Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food

Alexandra Malachová, Milena Stránská, Marta Václavíková, Christopher T. Elliott, Connor Black, Julie Meneely, Jana Hajšlová, Chibundu N. Ezekiel, Rainer Schuhmacher, Rudolf Krska*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)
219 Downloads (Pure)

Abstract

Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC–MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC–MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC–MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants.

Original languageEnglish
Pages (from-to)801-825
JournalAnalytical and Bioanalytical Chemistry
Volume410
Issue number3
Early online date22 Dec 2017
DOIs
Publication statusPublished - 01 Jan 2018

Keywords

  • Fungal secondary metabolites
  • Liquid chromatography–high-resolution mass spectrometry
  • Liquid chromatography–tandem mass spectrometry
  • Metabolomics
  • Validation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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