Advanced LC–MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food

Alexandra Malachová, Milena Stránská, Marta Václavíková, Christopher T. Elliott, Connor Black, Julie Meneely, Jana Hajšlová, Chibundu N. Ezekiel, Rainer Schuhmacher, Rudolf Krska*

*Corresponding author for this work

Research output: Contribution to journalReview article

38 Citations (Scopus)
204 Downloads (Pure)

Abstract

Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC–MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC–MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC–MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants.

Original languageEnglish
Pages (from-to)801-825
JournalAnalytical and Bioanalytical Chemistry
Volume410
Issue number3
Early online date22 Dec 2017
DOIs
Publication statusPublished - 01 Jan 2018

Keywords

  • Fungal secondary metabolites
  • Liquid chromatography–high-resolution mass spectrometry
  • Liquid chromatography–tandem mass spectrometry
  • Metabolomics
  • Validation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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