Advanced manufacturing of peptide nanomaterials

Essyrose Mathew, Edward Weaver, Raul Cazorla Luna, Emilia Utomo, Eneko Larrañeta, Dimitrios Lamprou*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

This book chapter aims to cover recent advanced research in the field of peptide nanomaterials. Peptide research is gaining more interest as the knowledge around their role in pathophysiology becomes better understood. Peptides are highly specific, can have low toxicity and be easily scaled up for manufacture; however, they are prone to enzymatic degradation within the body and are poorly permeable through biological membranes which can inhibit efficient and targeted delivery in the body. New manufacturing techniques are being explored to improve the stability of peptide formulations and bioavailability of these formulations in the body. This book chapter will cover three main manufacturing techniques. Microfluidics, exploring the encapsulation and incorporation of peptide into the nanoparticle shell as well as diagnostic uses. Electrospinning and incorporation of proteins and peptides for drug delivery and other biomedical applications. Additive manufacturing and how varying 3D printing techniques can be combined with peptide formulations for effective drug delivery.
Original languageEnglish
Title of host publicationPeptide Bionanomaterials: From Design to Application
EditorsMohamed Elsawy
PublisherSpringer
Chapter12
Publication statusAccepted - 10 Sep 2021

Keywords

  • Bioprinting
  • 3D Printing
  • Electrospinning
  • Microfluidics
  • Peptides
  • Drug Delivery Systems
  • Nanoparticles
  • Nanomedicine
  • Liposomes

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