Advanced materials for recognition and capture of whole cells and microorganisms

Amanda L. Bole, Panagiotis Manesiotis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Selective cell recognition and capture has recently attracted significant interest due to its potential importance for clinical, diagnostic, environmental, and security applications. Current methods for cell isolation from complex samples are largely dependent on cell size and density, with limited application scope as many of the target cells do not exhibit appreciable differences in this respect. The most recent and forthcoming developments in the area of selective recognition and capture of whole cells, based on natural receptors, as well as synthetic materials utilising physical and chemical properties of the target cell or microorganism, are highlighted. Particular focus is given to the development of cell complementary surfaces using the cells themselves as templating agents, by means of molecular imprinting, and their combination with sensing platforms for rapid cell detection in complex media. The benefits and challenges of each approach are discussed and a perspective of the future of this research area is given.
Original languageEnglish
Pages (from-to)5349-5366
Number of pages18
JournalAdvanced Materials
Volume28
Issue number27
Early online date12 Dec 2015
DOIs
Publication statusPublished - 20 Jul 2016

Fingerprint

Microorganisms
Artificial Receptors
Chemical properties
Physical properties
Molecular Imprinting
Cell Separation
Cell Size
Cell Count
Research

Keywords

  • cell recognition
  • molecular imprinting
  • bacteria detection
  • cancer
  • circulating tumour cells

Cite this

@article{2011ce21462d43de8028ee1938a3e138,
title = "Advanced materials for recognition and capture of whole cells and microorganisms",
abstract = "Selective cell recognition and capture has recently attracted significant interest due to its potential importance for clinical, diagnostic, environmental, and security applications. Current methods for cell isolation from complex samples are largely dependent on cell size and density, with limited application scope as many of the target cells do not exhibit appreciable differences in this respect. The most recent and forthcoming developments in the area of selective recognition and capture of whole cells, based on natural receptors, as well as synthetic materials utilising physical and chemical properties of the target cell or microorganism, are highlighted. Particular focus is given to the development of cell complementary surfaces using the cells themselves as templating agents, by means of molecular imprinting, and their combination with sensing platforms for rapid cell detection in complex media. The benefits and challenges of each approach are discussed and a perspective of the future of this research area is given.",
keywords = "cell recognition, molecular imprinting, bacteria detection, cancer, circulating tumour cells",
author = "Bole, {Amanda L.} and Panagiotis Manesiotis",
year = "2016",
month = "7",
day = "20",
doi = "10.1002/adma.201503962",
language = "English",
volume = "28",
pages = "5349--5366",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "27",

}

Advanced materials for recognition and capture of whole cells and microorganisms. / Bole, Amanda L.; Manesiotis, Panagiotis.

In: Advanced Materials, Vol. 28, No. 27, 20.07.2016, p. 5349-5366.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Advanced materials for recognition and capture of whole cells and microorganisms

AU - Bole, Amanda L.

AU - Manesiotis, Panagiotis

PY - 2016/7/20

Y1 - 2016/7/20

N2 - Selective cell recognition and capture has recently attracted significant interest due to its potential importance for clinical, diagnostic, environmental, and security applications. Current methods for cell isolation from complex samples are largely dependent on cell size and density, with limited application scope as many of the target cells do not exhibit appreciable differences in this respect. The most recent and forthcoming developments in the area of selective recognition and capture of whole cells, based on natural receptors, as well as synthetic materials utilising physical and chemical properties of the target cell or microorganism, are highlighted. Particular focus is given to the development of cell complementary surfaces using the cells themselves as templating agents, by means of molecular imprinting, and their combination with sensing platforms for rapid cell detection in complex media. The benefits and challenges of each approach are discussed and a perspective of the future of this research area is given.

AB - Selective cell recognition and capture has recently attracted significant interest due to its potential importance for clinical, diagnostic, environmental, and security applications. Current methods for cell isolation from complex samples are largely dependent on cell size and density, with limited application scope as many of the target cells do not exhibit appreciable differences in this respect. The most recent and forthcoming developments in the area of selective recognition and capture of whole cells, based on natural receptors, as well as synthetic materials utilising physical and chemical properties of the target cell or microorganism, are highlighted. Particular focus is given to the development of cell complementary surfaces using the cells themselves as templating agents, by means of molecular imprinting, and their combination with sensing platforms for rapid cell detection in complex media. The benefits and challenges of each approach are discussed and a perspective of the future of this research area is given.

KW - cell recognition

KW - molecular imprinting

KW - bacteria detection

KW - cancer

KW - circulating tumour cells

U2 - 10.1002/adma.201503962

DO - 10.1002/adma.201503962

M3 - Article

VL - 28

SP - 5349

EP - 5366

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 27

ER -