Advanced materials for recognition and capture of whole cells and microorganisms

Amanda L. Bole, Panagiotis Manesiotis

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Selective cell recognition and capture has recently attracted significant interest due to its potential importance for clinical, diagnostic, environmental, and security applications. Current methods for cell isolation from complex samples are largely dependent on cell size and density, with limited application scope as many of the target cells do not exhibit appreciable differences in this respect. The most recent and forthcoming developments in the area of selective recognition and capture of whole cells, based on natural receptors, as well as synthetic materials utilising physical and chemical properties of the target cell or microorganism, are highlighted. Particular focus is given to the development of cell complementary surfaces using the cells themselves as templating agents, by means of molecular imprinting, and their combination with sensing platforms for rapid cell detection in complex media. The benefits and challenges of each approach are discussed and a perspective of the future of this research area is given.
Original languageEnglish
Pages (from-to)5349-5366
Number of pages18
JournalAdvanced Materials
Volume28
Issue number27
Early online date12 Dec 2015
DOIs
Publication statusPublished - 20 Jul 2016

Keywords

  • cell recognition
  • molecular imprinting
  • bacteria detection
  • cancer
  • circulating tumour cells

ASJC Scopus subject areas

  • Analytical Chemistry
  • Oncology
  • Materials Science (miscellaneous)
  • Cancer Research

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