Abstract
DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates are the prevalent oxidized nucleotides, which can be misincorporated during replication, leading to mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy, combined with calculations, for the identification, detection, and quantification of oxidized nucleotides at low concentration. We also show that the Raman signature in the terahertz spectral range (
Original language | English |
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Pages (from-to) | 10825-10833 |
Journal | Analytical Chemistry |
Volume | 93 |
Issue number | 31 |
Early online date | 29 Jul 2021 |
DOIs | |
Publication status | Published - 10 Aug 2021 |
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Dive into the research topics of 'Advanced Raman Spectroscopy Detection of Oxidative Damage in Nucleic Acid Bases: Probing Chemical Changes and Intermolecular Interactions in Guanosine at Ultralow Concentration'. Together they form a unique fingerprint.Student theses
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Probing molecular adsorption on nobel metal nanosurfaces with surface-enhanced raman spectroscopy
Li, C. (Author), Bell, S. (Supervisor) & Nockemann, P. (Supervisor), Jul 2022Student thesis: Doctoral Thesis › Doctor of Philosophy