Advancing Strongyloides omics data: bridging the gap with Caenorhabditis elegans

Reem Al-Jawabreh, Dominika Lastik, Darrin McKenzie, Kieran Reynolds, Mona Suleiman, Angela Mousley, Louise Atkinson*, Vicky Hunt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
36 Downloads (Pure)


Among nematodes, the free-living model organism Caenorhabditis elegans boasts the most advanced portfolio of high-quality omics data. The resources available for parasitic nematodes, including Strongyloides spp., however, are lagging behind. While C. elegans remains the most tractable nematode and has significantly advanced our understanding of many facets of nematode biology, C. elegans is not suitable as a surrogate system for the study of parasitism and it is important that we improve the omics resources available for parasitic nematode species. Here, we review the omics data available for Strongyloides spp. and compare the available resources to those for C. elegans and other parasitic nematodes. The advancements in C. elegans omics offer a blueprint for improving omics-led research in Strongyloides. We suggest areas of priority for future research that will pave the way for expansions in omics resources and technologies. This article is part of the Theo Murphy meeting issue ‘Strongyloides: omics to worm-free populations’.
Original languageEnglish
Article number20220437
Number of pages22
JournalPhilosophical Transactions of the Royal Society B
Issue number1894
Early online date27 Nov 2023
Publication statusPublished - 15 Jan 2024


  • transposable elements
  • genomics
  • Strongyloides
  • proteomics
  • transcriptomics
  • small RNA


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