Adventures in the pharmacological analysis of P2 receptors

M.S. Fagura, Gavin Jarvis, I.G. Dougall, P. Leff

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The pharmacological classification of P2 receptors owes its origin to the pioneering efforts of Geoff Burnstock and those who followed him, research that was conducted primarily in physiological experimental systems. Over recent years, the techniques of molecular biology have been increasingly applied in the study of P2 receptors while, at the same time, advances in their pharmacological analysis have been limited by a lack of potent and selective agonist or antagonist ligands. This has resulted in a classification scheme which is largely structural in nature, with relatively little contribution from pharmacology. Our endeavours in this area have been directed towards the discovery of ligands with which the pharmacological analysis and definition of P2 receptors could be advanced, the ultimate goal being the design of therapeutic agents. This article will describe some of our experiences in this challenging but rewarding Nea. (C) 2000 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)178-186
Number of pages9
JournalJournal of the Autonomic Nervous System
Issue number1-3
Publication statusPublished - 03 Jul 2000

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

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