Affinity-Purified Respiratory Syncytial Virus Antibodies from Intravenous Immunoglobulin Exert Potent Antibody-Dependent Cellular Cytotoxicity

Nimesh Gupta, Jerome LeGoff, Soulaima Chamat, Severine Mercier-Delarue, Olivier Touzelet, Ultan F. Power, Michael D. Kazatchkine, Francois Simon, Sebastien Lacroix-Desmazes, Srini Kavari, Jagadeesh Bayry

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
219 Downloads (Pure)

Abstract

Mixed infections are one of the major therapeutic challenges, as the current strategies have had limited success. One of the most common and widespread conditions of mixed infection is respiratory syncytial virus-mediated pathology of the respiratory tract in children. There is a dire need for the development of novel therapeutic approaches during mixed infections. Therapeutic intravenous immunoglobulin preparations, obtained from plasma pools of healthy donors have been used in immune deficiencies. This study was thus designed to characterize the functional efficacy of RSV-specific antibodies in IVIg. To explore the functional ability of these affinity-purified RSV-specific antibodies, the antibody-dependent and complement dependent cytotoxicity was determined using peripheral cells of healthy donors. This study demonstrates the existence of highly potent RSV-specific antibodies in IVIg preparations and provides the basis for the use of IVIg as broad-spectrum protective shield to RSV-infected children during mixed infections
Original languageEnglish
Article numbere69390
Number of pages5
JournalPLoS ONE
Volume8
Issue number7
DOIs
Publication statusPublished - 19 Jul 2013

Keywords

  • Respiratory syncytial virus
  • Anti-RSV G protein human immunoglobulin
  • antibody-dependent cellular cytotoxicity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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