TY - JOUR
T1 - Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects
T2 - The Zenith Study
AU - Hininger-Favier, Isabelle
AU - Andriollo-Sanchez, Maud
AU - Arnaud, Josiane
AU - Meunier, Nathalie
AU - Bord, Séverine
AU - Graham, Ciaren
AU - Polito, Angela
AU - Maiani, Giuseppe
AU - O'Connor, Jacqueline M.
AU - Coudray, Charles
AU - Roussel, Anne Marie
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.
AB - Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.
KW - Elderly
KW - Trace element interactions
KW - Trace element-lipid interactions
KW - Zinc status
KW - Zinc supplementation
UR - http://www.scopus.com/inward/record.url?scp=34047251998&partnerID=8YFLogxK
U2 - 10.1017/S0007114507432974
DO - 10.1017/S0007114507432974
M3 - Article
C2 - 17313720
AN - SCOPUS:34047251998
SN - 0007-1145
VL - 97
SP - 569
EP - 578
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 3
ER -