Age-Associated Changes of Brain Copper, Iron, and Zinc in Alzheimer's Disease and Dementia with Lewy Bodies

Stewart F Graham, Muhammad Bin Nasaruddin, Manus Carey, Christian Holscher, Bernadette McGuinness, Patrick G Kehoe, Seth Love, Peter Passmore, Christopher T Elliott, Andrew A Meharg, Brian D Green

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Disease-, age-, and gender-associated changes in brain copper, iron, and zinc were assessed in postmortem neocortical tissue (Brodmann area 7) from patients with moderate Alzheimer's disease (AD) (n = 14), severe AD (n = 28), dementia with Lewy bodies (n = 15), and normal age-matched control subjects (n = 26). Copper was lower (20%; p < 0.001) and iron higher (10–16%; p < 0.001) in severe AD compared with controls. Intriguingly significant Group*Age interactions were observed for both copper and iron, suggesting gradual age-associated decline of these metals in healthy non-cognitively impaired individuals. Zinc was unaffected in any disease pathologies and no age-associated changes were apparent. Age-associated changes in brain elements warrant further investigation.
Original languageEnglish
Pages (from-to)1407-1413
JournalJournal of Alzheimer's disease : JAD
Volume42
Issue number4
Early online date11 Jul 2014
DOIs
Publication statusPublished - 13 Oct 2014

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