Age-related reference intervals for lymphocyte subsets in whole blood of healthy individuals

S E McNerlan, H D Alexander, I M Rea

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Enumeration of various lymphocyte subsets is used widely in the diagnosis and monitoring of various disease states. With the development of flow cytometric technology and whole blood analysis, methodologies have become more sensitive. It is therefore important to establish reference intervals in normal, healthy individuals using these techniques to give a better indication of the border between health and disease. Since some lymphocyte subpopulations are known to change with age, we have enumerated common subsets in healthy individuals from all decades of adult life, including nonagenarian subjects. We report reference intervals for these subsets in each age group, which will be of use in diagnosis and disease monitoring, particularly in elderly subjects, the most rapidly expanding group within the population today.
Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalScandinavian journal of clinical and laboratory investigation
Issue number2
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Biochemistry


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